2l5r: Difference between revisions
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New page: '''Unreleased structure''' The entry 2l5r is ON HOLD Authors: Subasinghage, A.P., Hewage, C.M., Conlon, M. Description: Conformational and membrane interactins studies of antimicrobial... |
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==Conformational and membrane interactins studies of antimicrobial peptide Alyteserin-1C== | |||
<StructureSection load='2l5r' size='340' side='right'caption='[[2l5r]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2l5r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Alytes_obstetricans Alytes obstetricans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L5R FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l5r OCA], [https://pdbe.org/2l5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l5r RCSB], [https://www.ebi.ac.uk/pdbsum/2l5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l5r ProSAT]</span></td></tr> | |||
'' | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/ATI1C_ALYOB ATI1C_ALYOB] Antibacterial peptide with amphipathic alpha-helical structure that shows selective growth-inhibitory activity against Gram-negative bacteria but low hemolytic activity against human erythrocytes (LC(50)=145-220 uM) (PubMed:19463738, PubMed:21565166). It is moderately active against the Gram-negative bacteria E.coli (MIC=25 uM), K.pneumoniae (MIC=50 uM), P.aeruginosa (MIC=25 uM), A.baumannii (MIC=6 uM), and is weaky active against the Gram-positive S.aureus (MIC=100-250 uM) (PubMed:19463738, PubMed:21565166).<ref>PMID:19463738</ref> <ref>PMID:21565166</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Alytes obstetricans]] | |||
[[Category: Large Structures]] | |||
[[Category: Conlon M]] | |||
[[Category: Hewage CM]] | |||
[[Category: Subasinghage AP]] | |||
Latest revision as of 06:53, 1 May 2024
Conformational and membrane interactins studies of antimicrobial peptide Alyteserin-1C
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