2xsn: Difference between revisions
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New page: '''Unreleased structure''' The entry 2xsn is ON HOLD Authors: Muniz, J.R.C., Cooper, C., Yue, W.W., Krysztofinska, E., vonDelft, F., Knapp, S., Arrowsmith, C.H., Edwards, A.M., Weigelt,... |
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The entry | ==Crystal Structure of Human Tyrosine Hydroxylase Catalytic Domain== | ||
<StructureSection load='2xsn' size='340' side='right'caption='[[2xsn]], [[Resolution|resolution]] 2.68Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2xsn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XSN FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.68Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xsn OCA], [https://pdbe.org/2xsn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xsn RCSB], [https://www.ebi.ac.uk/pdbsum/2xsn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xsn ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/TY3H_HUMAN TY3H_HUMAN] Autosomal recessive dopa-responsive dystonia. The disease is caused by mutations affecting the gene represented in this entry. May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls.<ref>PMID:20809526</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TY3H_HUMAN TY3H_HUMAN] Plays an important role in the physiology of adrenergic neurons. | |||
==See Also== | |||
*[[Hydroxylases 3D structures|Hydroxylases 3D structures]] | |||
*[[Monooxygenase 3D structures|Monooxygenase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bountra C]] | |||
[[Category: Cooper CDO]] | |||
[[Category: Edwards AM]] | |||
[[Category: Gileadi O]] | |||
[[Category: Kavanagh KL]] | |||
[[Category: Knapp S]] | |||
[[Category: Krysztofinska E]] | |||
[[Category: Muniz JRC]] | |||
[[Category: Oppermann U]] | |||
[[Category: Weigelt J]] | |||
[[Category: Yue WW]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 08:03, 23 August 2023
Crystal Structure of Human Tyrosine Hydroxylase Catalytic Domain
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