2r9n: Difference between revisions

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New page: left|200px<br /><applet load="2r9n" size="350" color="white" frame="true" align="right" spinBox="true" caption="2r9n, resolution 2.00Å" /> '''Cathepsin S complexe...
 
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[[Image:2r9n.jpg|left|200px]]<br /><applet load="2r9n" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2r9n, resolution 2.00&Aring;" />
'''Cathepsin S complexed with Compound 26'''<br />


==About this Structure==
==Cathepsin S complexed with Compound 26==
2R9N is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=Y14:'>Y14</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9N OCA].  
<StructureSection load='2r9n' size='340' side='right'caption='[[2r9n]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
[[Category: Cathepsin S]]
== Structural highlights ==
<table><tr><td colspan='2'>[[2r9n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R9N FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Y14:N-[(1S)-2-{[(3S)-1-BENZYL-3-CYANOPYRROLIDIN-3-YL]AMINO}-1-(CYCLOHEXYLMETHYL)-2-OXOETHYL]MORPHOLINE-4-CARBOXAMIDE'>Y14</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9n OCA], [https://pdbe.org/2r9n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r9n RCSB], [https://www.ebi.ac.uk/pdbsum/2r9n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r9n ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r9/2r9n_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r9n ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Cathepsin 3D structures|Cathepsin 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Bekkali, Y.]]
[[Category: Bekkali Y]]
[[Category: Brown, M.L.]]
[[Category: Brown ML]]
[[Category: Capolino, A.]]
[[Category: Capolino A]]
[[Category: Crane, K.M.]]
[[Category: Crane KM]]
[[Category: DeTuri, M.]]
[[Category: DeTuri M]]
[[Category: Emmanuel, M.J.]]
[[Category: Emmanuel MJ]]
[[Category: Freeman, D.]]
[[Category: Freeman D]]
[[Category: Frye, L.L.]]
[[Category: Frye LL]]
[[Category: Girardot, M.]]
[[Category: Girardot M]]
[[Category: Grygon, C.A.]]
[[Category: Grygon CA]]
[[Category: Hao, M.H.]]
[[Category: Hao M-H]]
[[Category: Hrapchak, M.]]
[[Category: Hrapchak M]]
[[Category: Labadia, M.E.]]
[[Category: Labadia ME]]
[[Category: Liu, W.]]
[[Category: Liu W]]
[[Category: Morwick, T.]]
[[Category: Morwick T]]
[[Category: Nelson, R.]]
[[Category: Nelson R]]
[[Category: Peterson, J.D.]]
[[Category: Peterson JD]]
[[Category: Raymond, E.L.]]
[[Category: Raymond EL]]
[[Category: Spero, D.M.]]
[[Category: Spero DM]]
[[Category: Thomson, D.S.]]
[[Category: Thomson DS]]
[[Category: Wang, Y.]]
[[Category: Wang Y]]
[[Category: Ward, Y.D.]]
[[Category: Ward YD]]
[[Category: White, A.]]
[[Category: White A]]
[[Category: White, D.M.]]
[[Category: White DM]]
[[Category: Wildeson, J.]]
[[Category: Wildeson J]]
[[Category: Young, E.R.R.]]
[[Category: Young ERR]]
[[Category: Zindell, R.]]
[[Category: Zindell R]]
[[Category: Y14]]
[[Category: cathepsin]]
[[Category: glycoprotein]]
[[Category: hydrolase]]
[[Category: lysosome]]
[[Category: polymorphism]]
[[Category: protease]]
[[Category: thiol protease]]
[[Category: zymogen]]
 
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Retrieved from "https://proteopedia.org/2r9n"