2vdv: Difference between revisions
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New page: left|200px<br /><applet load="2vdv" size="350" color="white" frame="true" align="right" spinBox="true" caption="2vdv, resolution 2.3Å" /> '''STRUCTURE OF TRM8, M7... |
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== | ==Structure of trm8, m7G methylation enzyme== | ||
<StructureSection load='2vdv' size='340' side='right'caption='[[2vdv]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2vdv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VDV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VDV FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vdv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vdv OCA], [https://pdbe.org/2vdv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vdv RCSB], [https://www.ebi.ac.uk/pdbsum/2vdv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vdv ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TRMB_YEAST TRMB_YEAST] Methyltransferase that catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay. Both the D-stem and T-stem structures of tRNAs are required for efficient methyltransferase activity.[HAMAP-Rule:MF_03055]<ref>PMID:16387656</ref> <ref>PMID:17382321</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vd/2vdv_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vdv ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[TRNA methyltransferase 3D structures|TRNA methyltransferase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Blondeau K]] | |||
[[Category: Chaillet M]] | |||
[[Category: Blondeau | [[Category: Durand D]] | ||
[[Category: Chaillet | [[Category: Leulliot N]] | ||
[[Category: Durand | [[Category: Ulryck N]] | ||
[[Category: Leulliot | [[Category: Van Tilbeurgh H]] | ||
[[Category: Ulryck | |||
[[Category: | |||
Latest revision as of 07:07, 1 May 2024
Structure of trm8, m7G methylation enzyme
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