2xsn: Difference between revisions

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~~{{Seed}}~~

~~[[Image:2xsn.jpg|left|200px]]~~

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==Crystal Structure of Human Tyrosine Hydroxylase Catalytic Domain==

~~The line below this paragraph, containing~~ "~~STRUCTURE_2xsn~~"~~, creates the~~ "~~Structure Box~~" ~~on the page~~.

~~You may change~~ the ~~PDB parameter (which sets~~ the ~~PDB file loaded into the applet)~~

== Structural highlights ==

~~or the SCENE parameter~~ (~~which sets the initial scene displayed when the page is loaded~~),

<table><tr><td colspan='2'>[[2xsn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSN OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=2XSN FirstGlance].

~~or leave~~ the ~~SCENE parameter empty for the default display~~.

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.68Å</td></tr>

-->

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

~~{{STRUCTURE_2xsn| PDB~~=~~2xsn | SCENE~~= }}

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=2xsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xsn OCA], [https://pdbe.org/2xsn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xsn RCSB], [https://www.ebi.ac.uk/pdbsum/2xsn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xsn ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/TY3H_HUMAN TY3H_HUMAN] Autosomal recessive dopa-responsive dystonia. The disease is caused by mutations affecting the gene represented in this entry. May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls.<ref>PMID:20809526</ref>

== Function ==

[https://www.uniprot.org/uniprot/TY3H_HUMAN TY3H_HUMAN] Plays an important role in the physiology of adrenergic neurons.

==~~=CRYSTAL STRUCTURE OF HUMAN TYROSINE HYDROXYLASE CATALYTIC DOMAIN=~~==

==See Also==

*[[Hydroxylases 3D structures|Hydroxylases 3D structures]]

*[[Monooxygenase 3D structures|Monooxygenase 3D structures]]

==~~About this Structure~~==

== References ==

~~2XSN is a 4 chains structure with sequences from [http:~~//~~en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSN OCA].~~

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: ~~Tyrosine 3-monooxygenase~~]]

[[Category: Large Structures]]

[[Category: Arrowsmith~~, C H.~~]]

[[Category: Arrowsmith CH]]

[[Category: Bountra, C.]]

[[Category: Bountra C]]

[[Category: Cooper~~, C D.O.~~]]

[[Category: Cooper CDO]]

[[Category: Edwards~~, A M.~~]]

[[Category: Edwards AM]]

[[Category: Gileadi, O.]]

[[Category: Gileadi O]]

[[Category: Kavanagh~~, K L.~~]]

[[Category: Kavanagh KL]]

[[Category: Knapp, S.]]

[[Category: Knapp S]]

[[Category: Krysztofinska, E.]]

[[Category: Krysztofinska E]]

[[Category: Muniz~~, J R.C.~~]]

[[Category: Muniz JRC]]

[[Category: Oppermann, U~~.]]~~

[[Category: Oppermann U]]

~~[[Category: Vondelft, F.~~]]

[[Category: Weigelt J]]

[[Category: Weigelt, J.]]

[[Category: Yue WW]]

[[Category: Yue~~, W W.~~]]

[[Category: Von Delft F]]

[[Category: ~~Oxidoreductase~~]]

~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 18 00:47:00 2010''~~

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@@ Line 1: / Line 1: @@
-{{Seed}}
-[[Image:2xsn.jpg|left|200px]]
-<!--
+==Crystal Structure of Human Tyrosine Hydroxylase Catalytic Domain==
-The line below this paragraph, containing "STRUCTURE_2xsn", creates the "Structure Box" on the page.
+<StructureSection load='2xsn' size='340' side='right'caption='[[2xsn]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2xsn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XSN FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.68&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_2xsn|  PDB=2xsn  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xsn OCA], [https://pdbe.org/2xsn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xsn RCSB], [https://www.ebi.ac.uk/pdbsum/2xsn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xsn ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/TY3H_HUMAN TY3H_HUMAN] Autosomal recessive dopa-responsive dystonia. The disease is caused by mutations affecting the gene represented in this entry.  May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls.<ref>PMID:20809526</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/TY3H_HUMAN TY3H_HUMAN] Plays an important role in the physiology of adrenergic neurons.
-===CRYSTAL STRUCTURE OF HUMAN TYROSINE HYDROXYLASE CATALYTIC DOMAIN===
+==See Also==
+*[[Hydroxylases 3D structures|Hydroxylases 3D structures]]
+*[[Monooxygenase 3D structures|Monooxygenase 3D structures]]
-==About this Structure==
+== References ==
-XSN is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XSN OCA].
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Tyrosine 3-monooxygenase]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Arrowsmith CH]]
-[[Category: Bountra, C.]]
+[[Category: Bountra C]]
-[[Category: Cooper, C D.O.]]
+[[Category: Cooper CDO]]
-[[Category: Edwards, A M.]]
+[[Category: Edwards AM]]
-[[Category: Gileadi, O.]]
+[[Category: Gileadi O]]
-[[Category: Kavanagh, K L.]]
+[[Category: Kavanagh KL]]
-[[Category: Knapp, S.]]
+[[Category: Knapp S]]
-[[Category: Krysztofinska, E.]]
+[[Category: Krysztofinska E]]
-[[Category: Muniz, J R.C.]]
+[[Category: Muniz JRC]]
-[[Category: Oppermann, U.]]
+[[Category: Oppermann U]]
-[[Category: Vondelft, F.]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J.]]
+[[Category: Yue WW]]
-[[Category: Yue, W W.]]
+[[Category: Von Delft F]]
-[[Category: Oxidoreductase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 18 00:47:00 2010''