Leucine-rich repeat: Difference between revisions

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A large family of over 60,000 proteins feature horseshoe- or arc-shaped domains made of leucine-rich repeats, which are named for a repeated motif that always contains leucine.<ref>PMID: 20825685</ref>
The leucine-rich repeat (LRR) proteins are a large family of over 60,000 proteins found in viruses, bacteria, archaea, and eukaryotes that feature horseshoe- or arc-shaped domains made of leucine-rich repeating motifs.<ref>PMID: 20825685</ref> Presently, at least 144 structures with leucine-rich repeats are deposited at the [http://www.pdb.org/pdb/home/home.do RCSB Protein Data Bank].<ref>LRRML Database (Version 1.6: Released November 25, 2010): Conformational LRR XML-Database at http://tollml.lrz.de:8081/exist/rest//lrrml/releases/releases.xq</ref>
{{Structure
{{Template:Lrrapplet1}}
|PDB= 3e6j |SIZE=400|SCENE=Lamprey_Variable_Lymphocyte_Receptor/Defaultjmol/1|CAPTION= Lamprey Variable Lymphocyte Receptor ([[3e6j]]), resolution 1.67&Aring; (<scene name='Lamprey_Variable_Lymphocyte_Receptor/Defaultjmol/1'>initial scene</scene>)
<!--
|SITE=
<slideshow sequence="random" transition="fade" align="left" refresh="5500">
|LIGAND=
<div>[[Image:1m10complexsurf.png|330px|left|thumb| <span style="font-size:1.2em;">The human leucine-rich repeat family member [[Platelet-receptor glycoprotein Ib alpha|Platelet-receptor glycoprotein Ib alpha (blue) involved in Willebrand disease bound to the von Willebrand Factor A1 Domain (green surface)]].</span>]] </div>
|ACTIVITY=
<div>[[Image:1id5polyview3d.png|center|thumb|330px|<span style="font-size:1.2em;">Extracellular domain of Lingo-1 protein involved in inhibiting effective regrowth of axons after central nervous system damage, from [[2id5]].</span>]] </div>
|GENE=
<div>[[Image:3ciyPV3D.png|left|thumb|360px|<span style="font-size:1.2em;">Extracellular domain of mouse Toll-like receptor bound to double-stranded RNA which is a molecular signature of many viruses, from [[3ciy]].</span>]] </div>
|DOMAIN=
</slideshow>
|RELATEDENTRY=
-->
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e6j OCA], [http://www.ebi.ac.uk/pdbsum/3e6j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3e6j RCSB]</span>
}}


<br>&nbsp;<br>


Articles in Proteopedia concerning Leucine-rich repeat proteins include:
Articles in Proteopedia concerning Leucine-rich repeat proteins include:
 
*[[Human Follicle-Stimulating Hormone Complexed with its Receptor]]
**[[1xvd|Human Follicle Stimulating Hormone Complexed with its Receptor]]
*[[Variable lymphocyte receptor]]
**[[Variable Lymphocyte Receptor]]
*[[Lamprey Variable Lymphocyte Receptor]]
**[[Lamprey Variable Lymphocyte Receptor]]
*[[3g04|Leucine-rich repeat domain of Thyroid-Stimulating Hormone]]
*[[Toll-like Receptors|Toll-like receptors (TLRs)]], such as [[3ciy|Mouse Toll-like receptor bound to dsRNA]]
*[[Platelet-receptor glycoprotein Ib alpha|Platelet-receptor glycoprotein Ib alpha bound to the von Willebrand Factor A1 Domain]]
*[[2id5|Lingo-1 protein involved in inhibiting effective regrowth of axons after central nervous system damage]]
<br />
<br />
<!--
{{Template:Lrrapplet2}}
-->
To view automatically seeded indices concerning Leucine-rich repeat proteins<ref>PMID: 20825685</ref><ref>LRRML Database (Version 1.6: Released November 25, 2010): Conformational LRR XML-Database at http://tollml.lrz.de:8081/exist/rest//lrrml/releases/releases.xq</ref>, see:
*[[:Category:Leucine-rich repeat|Leucine-rich repeat]]
*[[:Category:Leucine-rich-repeat|Leucine-rich-repeat]]
*[[:Category:Leucine-rich repeat-containing protein 4|Leucine-rich repeat-containing protein 4]]
*[[:Category:Lrr|LRR]]
*[[:Category:Leucine-rich repeat glycoprotein|Leucine-rich repeat glycoprotein]]


{{STRUCTURE_1xwd|  PDB=1xwd  |  SCENE=  }}
To view automatically seeded indices concerning Leucine-rich repeat proteins, see:
**[[:Category:Leucine-rich repeat|Leucine-rich repeat]]
**[[:Category:Leucine-rich-repeat|Leucine-rich-repeat]]
**[[:Category:Leucine-rich repeat-containing protein 4|Leucine-rich repeat-containing protein 4]]
**[[:Category:Lrr|LRR]]
**[[:Category:Leucine-rich repeat glycoprotein ]]


==References==
==References and Notes==
<references/>
<references/> <!--Seems div for slideshow messed up connection to references above?-->


==See Also==
==See Also==
*[[Toll-like Receptors|Toll-like receptors (TLRs)]]
*[[Antibody]]


==Additional Literature==
==Additional Literature==
<ref group="xtra">PMID: 11751054</ref><ref group="xtra">PMID: 17517123</ref><ref group="xtra">PMID: 16231091</ref><ref group="xtra">PMID: 11967365</ref><references group="xtra"/>
<ref group="xtra">PMID: 11751054</ref><ref group="xtra">PMID: 17517123</ref><ref group="xtra">PMID: 19728889 </ref><ref group="xtra">PMID: 16231091</ref><ref group="xtra">PMID: 11967365</ref><ref group="xtra">PMID: 18510864</ref><ref group="xtra">PMID: 19627256</ref><ref group="xtra">PMID: 18986514</ref><ref group="xtra">PMID: 20084417</ref><references group="xtra"/>
 
==External Resources==
*[http://tollml.lrz.de:8081/exist/rest//lrrml/index.xq LRRML: a conformational database and an XML description of leucine-rich repeats (LRRs)]
*[http://tollml.lrz.de:8081/exist/rest//db/tollml/index.xq TOLLML Database: database of toll-like receptor structural motifs]
* [http://www.ssfa-gphr.de/index.php Web-Based Sequence-Structure-Function-Analysis of Glycoprotein Hormone Receptors site] features coverage of the ectodomain which hosts a series of leucine-rich repeats
[[Category:Topic Page]]
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