Sandbox c33: Difference between revisions
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<Structure load='1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine. | |||
Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor. | |||
It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease. | |||
Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 (W84 and F330). | |||
Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649 | |||
' size='500' frame='true' align='right' caption='Insert caption here' /> | |||
1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine. | |||
Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor. | |||
It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease. | |||
Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 (W84 and F330). | |||
Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649 | |||
shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine. | |||
Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor. | |||
It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease. | |||
Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 (). | |||
Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649 | |||
Copy and paste the following line where you want the scene link to appear (scroll down if needed) and edit the TextToBeDisplayed: | |||
<scene name='Sandbox_c33/Try_phenil/1'>W84 and F330</scene> <scene name='Sandbox_c33/Trip_fenil_tacrine | |||
<scene name='Sandbox_c33/Try_phenil_label | |||
<references/> <PMID:8415649/> | |||
{{Seed}} | |||
[[Image:101m.png|left|200px]] | |||
