2r7k: Difference between revisions

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New page: left|200px<br /><applet load="2r7k" size="350" color="white" frame="true" align="right" spinBox="true" caption="2r7k, resolution 2.10Å" /> '''Crystal structure of...
 
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[[Image:2r7k.jpg|left|200px]]<br /><applet load="2r7k" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2r7k, resolution 2.10&Aring;" />
'''Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with AMPPCP and AICAR'''<br />


==About this Structure==
==Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with AMPPCP and AICAR==
2R7K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=ACP:'>ACP</scene> and <scene name='pdbligand=AMZ:'>AMZ</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R7K OCA].  
<StructureSection load='2r7k' size='340' side='right'caption='[[2r7k]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2r7k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R7K FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=AMZ:AMINOIMIDAZOLE+4-CARBOXAMIDE+RIBONUCLEOTIDE'>AMZ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r7k OCA], [https://pdbe.org/2r7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r7k RCSB], [https://www.ebi.ac.uk/pdbsum/2r7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r7k ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PURP_METJA PURP_METJA] Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.<ref>PMID:15623504</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r7/2r7k_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r7k ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Single protein]]
[[Category: Ealick SE]]
[[Category: Ealick, S.E.]]
[[Category: White RH]]
[[Category: White, R.H.]]
[[Category: Zhang Y]]
[[Category: Zhang, Y.]]
[[Category: ACP]]
[[Category: AMZ]]
[[Category: CL]]
[[Category: SO4]]
[[Category: atp-binding]]
[[Category: atp-grasp superfamily]]
[[Category: ligase]]
[[Category: magnesium]]
[[Category: manganese]]
[[Category: metal-binding]]
[[Category: nucleotide-binding]]
 
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Retrieved from "https://proteopedia.org/2r7k"