2xyk: Difference between revisions

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{{Seed}}
[[Image:2xyk.jpg|left|200px]]


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==Group II 2-on-2 Hemoglobin from the Plant Pathogen Agrobacterium tumefaciens==
The line below this paragraph, containing "STRUCTURE_2xyk", creates the "Structure Box" on the page.
<StructureSection load='2xyk' size='340' side='right'caption='[[2xyk]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2xyk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrobacterium_tumefaciens Agrobacterium tumefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XYK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XYK FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
{{STRUCTURE_2xyk|  PDB=2xyk  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xyk OCA], [https://pdbe.org/2xyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xyk RCSB], [https://www.ebi.ac.uk/pdbsum/2xyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xyk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q7CX73_AGRFC Q7CX73_AGRFC]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Within the 2/2 hemoglobin sub-family, no group II 2/2Hbs from proteobacteria have been so far studied. Here we present the first structural characterization of a group II 2/2Hb from the soil and phytopathogenic bacterium Agrobacterium tumefaciens (At-2/2HbO). The crystal structure of ferric At-2/2HbO (reported at 2.1A resolution) shows the location of specific/unique heme distal site residues (e.g., His(42)CD1, a residue distinctive of proteobacteria group II 2/2Hbs) that surround a heme-liganded water molecule. A highly intertwined hydrogen-bonded network, involving residues Tyr(26)B10, His(42)CD1, Ser(49)E7, Trp(93)G8, and three distal site water molecules, stabilizes the heme-bound ligand. Such a structural organization suggests a path for diatomic ligand diffusion to/from the heme. Neither a similar distal site structuring effect nor the presence of distal site water molecules has been so far observed in group I and group III 2/2Hbs, thus adding new distinctive information to the complex picture of currently available 2/2Hb structural and functional data.


===GROUP II 2-ON-2 HEMOGLOBIN FROM THE PLANT PATHOGEN AGROBACTERIUM TUMEFACIENS===
Structural characterization of a group II 2/2 hemoglobin from the plant pathogen Agrobacterium tumefaciens.,Pesce A, Nardini M, Labarre M, Richard C, Wittenberg JB, Wittenberg BA, Guertin M, Bolognesi M Biochim Biophys Acta. 2010 Nov 9. PMID:21070893<ref>PMID:21070893</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2xyk" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_21070893}}, adds the Publication Abstract to the page
*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 21070893 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_21070893}}
__TOC__
 
</StructureSection>
==About this Structure==
2XYK is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Agrobacterium_tumefaciens Agrobacterium tumefaciens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XYK OCA].
 
==Reference==
<ref group="xtra">PMID:21070893</ref><references group="xtra"/>
[[Category: Agrobacterium tumefaciens]]
[[Category: Agrobacterium tumefaciens]]
[[Category: Bolognesi, M.]]
[[Category: Large Structures]]
[[Category: Guertin, M.]]
[[Category: Bolognesi M]]
[[Category: Labarre, M.]]
[[Category: Guertin M]]
[[Category: Nardini, M.]]
[[Category: LaBarre M]]
[[Category: Pesce, A.]]
[[Category: Nardini M]]
[[Category: Richard, C.]]
[[Category: Pesce A]]
[[Category: Wittenberg, B A.]]
[[Category: Richard C]]
[[Category: Wittenberg, J B.]]
[[Category: Wittenberg BA]]
[[Category: 2/2 hemoglobin]]
[[Category: Wittenberg JB]]
[[Category: Oxygen storage-transport complex]]
 
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Retrieved from "https://proteopedia.org/2xyk"