3mln: Difference between revisions

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{{Seed}}
[[Image:3mln.jpg|left|200px]]


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==DNA binding domain of Early B-cell Factor 1 (Ebf1) bound to DNA (crystal form II)==
The line below this paragraph, containing "STRUCTURE_3mln", creates the "Structure Box" on the page.
<StructureSection load='3mln' size='340' side='right'caption='[[3mln]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3mln]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MLN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MLN FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3mln|  PDB=3mln  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mln OCA], [https://pdbe.org/3mln PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mln RCSB], [https://www.ebi.ac.uk/pdbsum/3mln PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mln ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/COE1_MOUSE COE1_MOUSE] Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.<ref>PMID:20876732</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Early B-cell factor 1 (Ebf1) is a key transcriptional determinant of B-lymphocyte differentiation whose DNA-binding domain has no sequence similarity to other transcription factor families. Here we report the crystal structure of an Ebf1 dimer bound to its palindromic recognition site. The DNA-binding domain adopts a pseudoimmunoglobulin-like fold with novel topology, but is structurally similar to the Rel homology domains of NFAT and NF-kappaB. Ebf1 contacts the DNA with two loop-based modules and a unique Zn coordination motif whereby each Ebf1 monomer interacts with both palindromic half-sites. This unusual mode of DNA recognition generates an extended contact area that may be crucial for the function of Ebf1 in chromatin.


===DNA binding domain of Early B-cell Factor 1 (Ebf1) bound to DNA (crystal form II)===
Structure of an Ebf1:DNA complex reveals unusual DNA recognition and structural homology with Rel proteins.,Treiber N, Treiber T, Zocher G, Grosschedl R Genes Dev. 2010 Oct 15;24(20):2270-5. Epub 2010 Sep 28. PMID:20876732<ref>PMID:20876732</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3mln" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 20876732 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_20876732}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
3MLN is a 5 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MLN OCA].
 
==Reference==
<ref group="xtra">PMID:20876732</ref><references group="xtra"/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Grosschedl, R.]]
[[Category: Synthetic construct]]
[[Category: Treiber, N.]]
[[Category: Grosschedl R]]
[[Category: Treiber, T.]]
[[Category: Treiber N]]
[[Category: Zocher, G.]]
[[Category: Treiber T]]
[[Category: Dna]]
[[Category: Zocher G]]
[[Category: Pseudo-ig-fold]]
[[Category: Transcription factor]]
[[Category: Transcription-dna complex]]
[[Category: Zn-finger]]
[[Category: Zn-knuckle]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec  1 11:31:13 2010''
Retrieved from "https://proteopedia.org/3mln"