NodS: Difference between revisions
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===Chemical signals=== | ===Chemical signals=== | ||
The very first stage of this process is an exchange of chemical signals between the symbionts. On sensing a flavonoid compound released by the plant, the bacteria produce a signalling molecule known as Nod factor, which is a lipochitooligosaccharide derivative. This molecule in turn induces nodule formation by the plant.<ref>PMID: 18444906</ref><ref>PMID: 17632573</ref><ref>PMID: 1444265</ref> Many types of flavonoids and Nod factors are known and which ones are present influences the specificity of the interaction. It must be mentioned that while these two molecules are important signals and specificity determinants, there are numerous others.<ref>PMID: 20070373</ref><ref>PMID: 18616593</ref> | The very first stage of this process is an exchange of chemical signals between the symbionts. On sensing a flavonoid compound released by the plant, the bacteria produce a signalling molecule known as Nod factor, which is a lipochitooligosaccharide derivative. This molecule in turn induces nodule formation by the plant.<ref>PMID: 18444906</ref><ref>PMID: 17632573</ref><ref>PMID: 1444265</ref> Many types of flavonoids and Nod factors are known and which ones are present influences the specificity of the interaction. It must be mentioned that while these two molecules are important signals and specificity determinants, there are numerous others.<ref>PMID: 20070373</ref><ref>PMID: 18616593</ref> | ||
===Nod factor synthesis=== | ===Nod factor synthesis=== | ||
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==Structure and function of NodS== | ==Structure and function of NodS== | ||
<StructureSection load='3ofj' size='500' side='right' scene='User:Marcin_Jozef_Suskiewicz/Sandbox_MarcinSuskiewicz/Typical_fold/1' caption='Structure of NodS'> | <StructureSection load='3ofj' size='500' side='right' scene='User:Marcin_Jozef_Suskiewicz/Sandbox_MarcinSuskiewicz/Typical_fold/1' caption='Structure of NodS [[3ofj]]'> | ||
===Fold=== | ===Fold=== | ||
NodS is an S-adenosyl-L-methionine (SAM)-dependent methyltransferase that methylates the deacetylated nitrogen atom at the nonreducing end of the chitooligosaccharide substrate, converting at the same time the S-adenosyl-L-methionine methyl donor into S-adenosyl-L-homocysteine, which is then released as a by-product (see figure above).<ref>PMID: 7494487</ref> | NodS is an S-adenosyl-L-methionine (SAM)-dependent methyltransferase that methylates the deacetylated nitrogen atom at the nonreducing end of the chitooligosaccharide substrate, converting at the same time the S-adenosyl-L-methionine methyl donor into S-adenosyl-L-homocysteine, which is then released as a by-product (see figure above).<ref>PMID: 7494487</ref> | ||
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</StructureSection> | </StructureSection> | ||
==3D structures of NodS== | |||
[[3ofj]] – BrNodS – ''Bradyrhibozium''<br /> | |||
[[3ofk]] – BrNodS + adenosyl homocysteine<br /> | |||
[[2ocx]], [[2hhc]], [[2hlh]] – BrNodZ<br /> | |||
[[1fh1]] – NodF – ''Rhibozium leguminosarum''<br /> | |||
==Reference== | ==Reference== | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||
