2l74: Difference between revisions
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New page: '''Unreleased structure''' The entry 2l74 is ON HOLD Authors: Habazettl, J., Allan, M., Jenal, U., Jenal, S. Description: Solution Structure of the PilZ Domain Protein PA4608 Complex w... |
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==Solution structure of the PilZ domain protein PA4608 complex with c-di-GMP identifies charge clustering as molecular readout== | |||
<StructureSection load='2l74' size='340' side='right'caption='[[2l74]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2l74]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L74 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L74 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene></td></tr> | |||
'' | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l74 OCA], [https://pdbe.org/2l74 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l74 RCSB], [https://www.ebi.ac.uk/pdbsum/2l74 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l74 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CDGBP_PSEAE CDGBP_PSEAE] Binds the second messenger bis-(3'-5') cyclic dimeric guanosine monophosphate (c-di-GMP). Can bind two c-di-GMP molecules per monomer. May play a role in bacterial second-messenger regulated processes. Binding to c-di-GMP induces a conformational change of the C- and N-termini resulting in the exposure of a highly negative surface on one side of the protein to a possible effector protein.<ref>PMID:17096419</ref> <ref>PMID:21280119</ref> <ref>PMID:21310957</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Pseudomonas aeruginosa]] | |||
[[Category: Allan M]] | |||
[[Category: Grzesiek S]] | |||
[[Category: Habazettl J]] | |||
[[Category: Jenal U]] | |||
Latest revision as of 06:54, 1 May 2024
Solution structure of the PilZ domain protein PA4608 complex with c-di-GMP identifies charge clustering as molecular readout
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