3izq: Difference between revisions
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New page: '''Unreleased structure''' The entry 3izq is ON HOLD Authors: Becker, T., Armache, J.-P., Jarasch, A., Anger, A.M., Villa, E., Sieber, H., Abdel Motaal, B., Mielke, T., Berninghausen, O... |
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==Structure of the Dom34-Hbs1-GDPNP complex bound to a translating ribosome== | |||
<SX load='3izq' size='340' side='right' viewer='molstar' caption='[[3izq]], [[Resolution|resolution]] 9.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3izq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IZQ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 9.5Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3izq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3izq OCA], [https://pdbe.org/3izq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3izq RCSB], [https://www.ebi.ac.uk/pdbsum/3izq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3izq ProSAT]</span></td></tr> | |||
'' | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/DOM34_YEAST DOM34_YEAST] Involved in protein translation. Together with HBS1, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. The complex formed by DOM34 and HBS1 has ribonuclease activity towards double-stranded RNA substrates, but does not cleave single-stranded RNA. Acts as endonuclease; has no exonuclease activity. Increases the affinity of HBS1 for GTP, but nor for GDP. Promotes G1 progression and differentiation and is involved in mitotic and meiotic cell divisions.<ref>PMID:16554824</ref> <ref>PMID:17889667</ref> <ref>PMID:18180287</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</SX> | |||
[[Category: Large Structures]] | |||
[[Category: Saccharomyces cerevisiae]] | |||
[[Category: Abdel Motaal B]] | |||
[[Category: Anger AM]] | |||
[[Category: Armache J-P]] | |||
[[Category: Becker T]] | |||
[[Category: Beckmann R]] | |||
[[Category: Berninghausen O]] | |||
[[Category: Jarasch A]] | |||
[[Category: Mielke T]] | |||
[[Category: Sieber H]] | |||
[[Category: Villa E]] | |||
Latest revision as of 10:08, 21 February 2024
Structure of the Dom34-Hbs1-GDPNP complex bound to a translating ribosome
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