3psa: Difference between revisions
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New page: '''Unreleased structure''' The entry 3psa is ON HOLD Authors: Tirado-Lee, L, Lee, A, Rees, D.C., Pinkett, H.W. Description: Classification of a Haemophilus influenzae ABC transporter H... |
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The | ==Classification of a Haemophilus influenzae ABC transporter HI1470/71 through its cognate molybdate periplasmic binding protein MolA (MolA bound to tungstate)== | ||
<StructureSection load='3psa' size='340' side='right'caption='[[3psa]], [[Resolution|resolution]] 1.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3psa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PSA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PSA FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WO4:TUNGSTATE(VI)ION'>WO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3psa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3psa OCA], [https://pdbe.org/3psa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3psa RCSB], [https://www.ebi.ac.uk/pdbsum/3psa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3psa ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MOLA_HAEIN MOLA_HAEIN] Part of the ABC transporter complex MolBCA involved in molybdate import (PubMed:22078568, PubMed:24722984). Functions as a low-affinity molybdate transporter (PubMed:24722984). Binds to both molybdate and tungstate, but not to sulfate or phosphate (PubMed:22078568).<ref>PMID:22078568</ref> <ref>PMID:24722984</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
molA (HI1472) from H. influenzae encodes a periplasmic binding protein (PBP) that delivers substrate to the ABC transporter MolB(2)C(2) (formerly HI1470/71). The structures of MolA with molybdate and tungstate in the binding pocket were solved to 1.6 and 1.7 A resolution, respectively. The MolA-binding protein binds molybdate and tungstate, but not other oxyanions such as sulfate and phosphate, making it the first class III molybdate-binding protein structurally solved. The approximately 100 muM binding affinity for tungstate and molybdate is significantly lower than observed for the class II ModA molybdate-binding proteins that have nanomolar to low micromolar affinity for molybdate. The presence of two molybdate loci in H. influenzae suggests multiple transport systems for one substrate, with molABC constituting a low-affinity molybdate locus. | |||
Classification of a Haemophilus influenzae ABC Transporter HI1470/71 through Its Cognate Molybdate Periplasmic Binding Protein, MolA.,Tirado-Lee L, Lee A, Rees DC, Pinkett HW Structure. 2011 Nov 9;19(11):1701-10. PMID:22078568<ref>PMID:22078568</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 3psa" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Haemophilus influenzae]] | |||
[[Category: Large Structures]] | |||
[[Category: Lee A]] | |||
[[Category: Pinkett HW]] | |||
[[Category: Rees DC]] | |||
[[Category: Tirado-Lee L]] | |||
Latest revision as of 10:04, 13 August 2026
Classification of a Haemophilus influenzae ABC transporter HI1470/71 through its cognate molybdate periplasmic binding protein MolA (MolA bound to tungstate)
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