2v8s: Difference between revisions

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New page: left|200px<br /><applet load="2v8s" size="350" color="white" frame="true" align="right" spinBox="true" caption="2v8s, resolution 2.22Å" /> '''VTI1B HABC DOMAIN- E...
 
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[[Image:2v8s.gif|left|200px]]<br /><applet load="2v8s" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2v8s, resolution 2.22&Aring;" />
'''VTI1B HABC DOMAIN- EPSINR ENTH DOMAIN COMPLEX'''<br />


==About this Structure==
==VTI1B HABC DOMAIN - EPSINR ENTH DOMAIN COMPLEX==
2V8S is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Sites: <scene name='pdbsite=AC1:Gol Binding Site For Chain E'>AC1</scene>, <scene name='pdbsite=AC2:Gol Binding Site For Chain E'>AC2</scene>, <scene name='pdbsite=AC3:Gol Binding Site For Chain E'>AC3</scene>, <scene name='pdbsite=AC4:Gol Binding Site For Chain V'>AC4</scene> and <scene name='pdbsite=AC5:Gol Binding Site For Chain V'>AC5</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V8S OCA].  
<StructureSection load='2v8s' size='340' side='right'caption='[[2v8s]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2v8s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V8S FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v8s OCA], [https://pdbe.org/2v8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v8s RCSB], [https://www.ebi.ac.uk/pdbsum/2v8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v8s ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/EPN4_HUMAN EPN4_HUMAN] Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly.<ref>PMID:12429846</ref> <ref>PMID:12538641</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v8/2v8s_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v8s ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Collins, B.M.]]
[[Category: Collins BM]]
[[Category: Mccoy, A.J.]]
[[Category: McCoy AJ]]
[[Category: Miller, S.E.]]
[[Category: Miller SE]]
[[Category: Owen, D.J.]]
[[Category: Owen DJ]]
[[Category: GOL]]
[[Category: adaptor]]
[[Category: alternative splicing]]
[[Category: cargo]]
[[Category: clathrin]]
[[Category: coiled coil]]
[[Category: cytoplasm]]
[[Category: cytoplasmic vesicle]]
[[Category: endocytosis]]
[[Category: lipid-binding]]
[[Category: membrane]]
[[Category: phosphorylation]]
[[Category: protein transport]]
[[Category: snare]]
[[Category: transmembrane]]
[[Category: transport]]
[[Category: vesicle]]
[[Category: vti1b-epsinr complex]]
 
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Retrieved from "https://proteopedia.org/2v8s"