2x7h: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| (8 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Crystal structure of the human MGC45594 gene product in complex with fenoprofen== | |||
<StructureSection load='2x7h' size='340' side='right'caption='[[2x7h]], [[Resolution|resolution]] 1.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2x7h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X7H FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PFN:FENOPROFEN'>PFN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x7h OCA], [https://pdbe.org/2x7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x7h RCSB], [https://www.ebi.ac.uk/pdbsum/2x7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x7h ProSAT]</span></td></tr> | |||
</table> | |||
=== | == Function == | ||
[https://www.uniprot.org/uniprot/PTGR3_HUMAN PTGR3_HUMAN] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.[UniProtKB:Q8BGC4] | |||
__TOC__ | |||
== | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith | [[Category: Large Structures]] | ||
[[Category: Bountra | [[Category: Arrowsmith C]] | ||
[[Category: Chaikuad | [[Category: Bountra C]] | ||
[[Category: Edwards | [[Category: Chaikuad A]] | ||
[[Category: Niesen | [[Category: Edwards A]] | ||
[[Category: Oppermann | [[Category: Niesen F]] | ||
[[Category: Pike | [[Category: Oppermann U]] | ||
[[Category: Shafqat | [[Category: Pike ACW]] | ||
[[Category: Smee | [[Category: Shafqat N]] | ||
[[Category: Ugochukwu | [[Category: Smee C]] | ||
[[Category: Vollmar | [[Category: Ugochukwu E]] | ||
[[Category: Vollmar M]] | |||
[[Category: Weigelt | [[Category: Weigelt J]] | ||
[[Category: Yue | [[Category: Yue WW]] | ||
[[Category: | [[Category: Von Delft F]] | ||
Latest revision as of 10:37, 16 August 2023
Crystal structure of the human MGC45594 gene product in complex with fenoprofen
| ||||||||||||
