Tacrine: Difference between revisions

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* Importance: One of the the first treatments for the symptoms of [[Alzheimer's Disease]], although no definitive proof exists as to whether it alters the progression of the disease.  
* Importance: One of the the first treatments for the symptoms of [[Alzheimer's Disease]], although no definitive proof exists as to whether it alters the progression of the disease.  
* See: [[Pharmaceutical Drugs]] for more information about other drugs and disorders
* See: [[Pharmaceutical Drugs]] for more information about other drugs and disorders


===Mechanism of Action===
===Mechanism of Action===
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===Pharmacokinetics===
===Pharmacokinetics===
{| class="wikitable" border="1" width="47%" style="text-align:center"
<table style="background: cellspacing="0px" align="" cellpadding="0px" width="42%">  
|-
<tr>
!  colspan="7" align="center"| Aceylcholinesterase Inhibitor [[Pharmacokinetics]]<ref>PMID:17113365</ref><ref>PMID: 19935404</ref><ref>PMID:7605915</ref><ref>PMID:1404819</ref><ref>doi:10.1053/cp.1999.v66.103404001</ref><ref>doi:10.1038/sj.clpt.6100242</ref><ref>PMID:12734391</ref><ref>PMID: 11741490</ref>
<td style="width:100%; vertical-align:top;border-width:0px; border-style:inset">
|-
<div style="height:100%; width: 100%">
! Parameter
{{:Acetylcholinesterase Inhibitor Pharmacokinetics}}
! [[Donepezil]]
</div>
! [[Tacrine]]
</td>
! [[Rivastigmine]]
</tr>
! [[Galantamine]]
</table>
|-
! [[Pharmacokinetics#Tmax|T<sub>max</sub>]] (hr)
! 3.6
! 1.5
! .3
! 1.2
|-
! [[Pharmacokinetics#Cmax|C<sub>max</sub>]] (ng/ml)
! 6.5
! 15.7
! 29.3
! 42.6
|-
! [[Pharmacokinetics#Bioavailability_.28F.29|Bioavailability]] (%)
! 100
! 17
! 36
! 100
|-
! [[Pharmacokinetics#Protein_Binding|Protein Binding]] (%)
! 96
! 55
! 40
! 10
|-
! [[Pharmacokinetics#Half_Life_.28T1.2F2.29|T<sub>1/2</sub>]] (hr)
! 70
! 3
! 5
! 7.3
|-
! [[Pharmacokinetics#Area_Under_the_Curve_.28AUC.29|AUC]] (ng/ml/hr)
! 380
! 80.4
! 191
! 427
|-
! [[Pharmacokinetics#Inhibitory_Concentration_.28IC50.29|IC<sub>50</sub>]] (nM)
! 6.7 <br/>(Rat)
! 450 <br/>(Human)
! 1535 <br/>(Human)
! 1995 <br/>(Rat)
|-
! Dosage (mg)
! 5
! 160
! 6
! 8
|-
! Metabolism
! Hepatic (CYP2D6 & CYP3A4) & Cholinesterase
! Hepatic (CYP1A2) & Cholinesterase
! Cholinesterase
! Hepatic (CYP3A4 & CYP2D6) & Cholinesterase
|}


===References===
===References===
Retrieved from "https://proteopedia.org/Tacrine"