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New page: left|200px<br /><applet load="2ntt" size="350" color="white" frame="true" align="right" spinBox="true" caption="2ntt, resolution 1.561Å" /> '''Crystal Structure o...
 
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[[Image:2ntt.gif|left|200px]]<br /><applet load="2ntt" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2ntt, resolution 1.561&Aring;" />
'''Crystal Structure of SEK'''<br />


==Overview==
==Crystal Structure of SEK==
Superantigens (SAGs) interact with host immune receptors to induce a, massive release of inflammatory cytokines that can lead to toxic shock, syndrome and death. Bacterial SAGs can be classified into five distinct, evolutionary groups. Group V SAGs are characterized by the alpha3-beta8, loop, a unique approximately 15 amino acid residue extension that is, required for optimal T cell activation. Here, we report the X-ray crystal, structures of the group V SAG staphylococcal enterotoxin K (SEK) alone and, in complex with the TCR hVbeta5.1 domain. SEK adopts a unique TCR binding, orientation relative to other SAG-TCR complexes, which results in the, alpha3-beta8 loop contacting the apical loop of framework region 4, thereby extending the known TCR recognition site of SAGs. These, interactions are absolutely required for TCR binding and T cell activation, by SEK, and dictate the TCR Vbeta domain specificity of SEK and other, group V SAGs.
<StructureSection load='2ntt' size='340' side='right'caption='[[2ntt]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[2ntt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_COL Staphylococcus aureus subsp. aureus COL]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NTT FirstGlance]. <br>
2NTT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] with <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=EDO:'>EDO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NTT OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.561&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ntt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ntt OCA], [https://pdbe.org/2ntt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ntt RCSB], [https://www.ebi.ac.uk/pdbsum/2ntt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ntt ProSAT]</span></td></tr>
A Novel Loop Domain in Superantigens Extends their T Cell Receptor Recognition Site., Gunther S, Varma AK, Moza B, Kasper KJ, Wyatt AW, Zhu P, Rahman AK, Li Y, Mariuzza RA, McCormick JK, Sundberg EJ, J Mol Biol. 2007 May 18;. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17560605 17560605]
</table>
[[Category: Single protein]]
== Function ==
[[Category: Staphylococcus aureus]]
[https://www.uniprot.org/uniprot/Q93CC5_STAAU Q93CC5_STAAU]
[[Category: Gunther, S.]]
== Evolutionary Conservation ==
[[Category: Moza, B.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Sundberg, E.J.]]
Check<jmol>
[[Category: Varma, A.K.]]
  <jmolCheckbox>
[[Category: CL]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nt/2ntt_consurf.spt"</scriptWhenChecked>
[[Category: EDO]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: superantigen; t cell receptor]]
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:02:36 2008''
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ntt ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus subsp. aureus COL]]
[[Category: Gunther S]]
[[Category: Moza B]]
[[Category: Sundberg EJ]]
[[Category: Varma AK]]
Retrieved from "https://proteopedia.org/2ntt"