2l76: Difference between revisions
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New page: '''Unreleased structure''' The entry 2l76 is ON HOLD Authors: Wu, B., Yee, A., Houliston, S., Doherty, R., Semesi, A., Dhe-Paganon, S., Arrowsmith, C.H. Description: Solution NMR struc... |
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==Solution NMR structure of human NFATC2IP ubiquitin-like domain, NFATC2IP_244_338, NESG target HT65A/OCSP target hs00387_244_338/SGC-toronto== | |||
<StructureSection load='2l76' size='340' side='right'caption='[[2l76]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2l76]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L76 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l76 OCA], [https://pdbe.org/2l76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l76 RCSB], [https://www.ebi.ac.uk/pdbsum/2l76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l76 ProSAT]</span></td></tr> | |||
'' | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/NF2IP_HUMAN NF2IP_HUMAN] In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Dhe-Paganon S]] | |||
[[Category: Doherty R]] | |||
[[Category: Houliston S]] | |||
[[Category: Semesi A]] | |||
[[Category: Wu B]] | |||
[[Category: Yee A]] | |||
Latest revision as of 05:39, 15 May 2024
Solution NMR structure of human NFATC2IP ubiquitin-like domain, NFATC2IP_244_338, NESG target HT65A/OCSP target hs00387_244_338/SGC-toronto
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