2xzt: Difference between revisions

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'''Unreleased structure'''


The entry 2xzt is ON HOLD  until Paper Publication
==Caspase-3 in Complex with DARPin-3.4_I78S==
<StructureSection load='2xzt' size='340' side='right'caption='[[2xzt]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2xzt]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XZT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xzt OCA], [https://pdbe.org/2xzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xzt RCSB], [https://www.ebi.ac.uk/pdbsum/2xzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xzt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>


Authors: Barandun, J., Schroeder, T., Mittl, P., Grutter, M.G.
==See Also==
 
*[[Caspase 3D structures|Caspase 3D structures]]
Description: Caspase-3 in Complex with DARPin-3.4_I78S
== References ==
 
<references/>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 15 08:17:13 2010''
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Barandun J]]
[[Category: Grutter MG]]
[[Category: Mittl P]]
[[Category: Schroeder T]]
Retrieved from "https://proteopedia.org/2xzt"