Disintegrin: Difference between revisions
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New page: left|200px|thumb|Crystal Structure of Disintegrin [[1z1x]] {{STRUCTURE_1z1x| PDB=1z1x | SIZE=300| SCENE= |right|CAPTION=Disintegrin 1z1x }} |
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[[ | <StructureSection load='' size='350' side='right' scene='Disintegrin/Cv/1' caption='Disintegrin, [[1z1x]]'> | ||
== Function == | |||
[[Disintegrin|Disintegrins]] are a family of cysteine-rich toxins from viper venoms which inhibit platelet aggregation and cell adhesion. <ref>PMID:15578957</ref> Over 100 disintegrins have been studied. | |||
== Relevance == | |||
Disintegrins, which have anti-integrin activity, have been the molecular scaffold used in the design of therapeutics for the prevention of thrombosis and cancer. Disintegrin also functions in inhibition of adipogenesis<ref>PMID:18508683</ref>. | |||
</StructureSection> | |||
== 3D Structures of Disintegrin == | |||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
[[2w9o]], [[2w9u]], [[2w9v]], [[2w9w]] – jerdostatin residues 68-110 – ''Trimeresurus jerdonii'' – NMR<br /> | |||
[[1j2l]] – trimestatin - ''Trimeresurus flavovidrius''<br /> | |||
[[2pjf]], [[1q7i]], [[1q7j]], [[1n4y]] – Cr rhodostoxin residues 1-68 – ''Calloselasma rhodostoma'' – NMR<br /> | |||
[[2pjg]], [[2pji]], [[2ljv]] - Cr rhodostoxin (mutant) 1-68 – NMR<br /> | |||
[[3uci]], [[26qz]], [[4r5r]], [[4r5u]], [[4rqg]] - Cr rhodostoxin (mutant) 408-475<br /> | |||
[[2m75]], [[2m7f]], [[2m7h]] - Cr rhodostoxin (mutant) 408-475 – NMR<br /> | |||
[[1z1x]], [[1tej]] – Ec disintegrin – ''Echis carinatus''<br /> | |||
[[1rmr]] – Ec schistatin<br /> | |||
[[6lsq]] – Ec echistatin<br /> | |||
[[1ro3]], [[2ech]] – Ec echistatin - NMR<br /> | |||
[[1l3x]] – salmosin – ''Gloydius brevicaudus'' – NMR<br /> | |||
[[1mpz]] – obtustatin – ''Macrovipera obtusa'' - NMR<br /> | |||
[[3c05]] – acostatin-α residues 48-109+acostatin-β residues 419-482 – copperhead<br /> | |||
[[3dsl]] – bothropasin - Jararaca<br /> | |||
[[2dw0]], [[2dw1]], [[2dw2]] – catrocollastatin – rattlesnake<br /> | |||
[[2mop]], [[2mp5]] – bitistatin – African puff adder - NMR<br /> | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | |||
