Disintegrin: Difference between revisions

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[[Image:1z1x.png|left|200px|thumb|Crystal Structure of Disintegrin [[1z1x]]]]
<StructureSection load='' size='350' side='right' scene='Disintegrin/Cv/1' caption='Disintegrin,  [[1z1x]]'>
{{STRUCTURE_1z1x|  PDB=1z1x  | SIZE=300| SCENE=Disintegrin/Cv/1 |right|CAPTION=Disintegrin [[1z1x]] }}
== Function ==


[[Disintegrin|Disintegrins]] are a family of toxins from viper venoms which inhibit platelet aggregation and cell adhesion. The images at the left and at the right correspond to one representative Disintegrin, ''i.e.'' the crystal structure of Disintegrin from ''Echis carinatus'' ([[1z1x]]).
[[Disintegrin|Disintegrins]] are a family of cysteine-rich toxins from viper venoms which inhibit platelet aggregation and cell adhesion. <ref>PMID:15578957</ref>  Over 100 disintegrins have been studied.
 
== Relevance ==
{{TOC limit|limit=2}}


Disintegrins, which have anti-integrin activity, have been the molecular scaffold used in the design of therapeutics for the prevention of thrombosis and cancer. Disintegrin also functions in inhibition of adipogenesis<ref>PMID:18508683</ref>.
</StructureSection>
== 3D Structures of Disintegrin ==
== 3D Structures of Disintegrin ==
 
 
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}


[[2w9o]], [[2w9u]], [[2w9v]], [[2w9w]] – jerdostatin residues 68-110 – ''Trimeresurus jerdonii'' – NMR<br />
[[2w9o]], [[2w9u]], [[2w9v]], [[2w9w]] – jerdostatin residues 68-110 – ''Trimeresurus jerdonii'' – NMR<br />
[[1j2l]] – trimestatin -  ''Trimeresurus flavovidrius''<br />
[[1j2l]] – trimestatin -  ''Trimeresurus flavovidrius''<br />
[[2pjf]], [[1q7i]], [[1q7j]] – Cr rhodostoxin residues 1-68 – ''Calloselasma rhodostoma'' – NMR<br />
[[2pjf]], [[1q7i]], [[1q7j]], [[1n4y]] – Cr rhodostoxin residues 1-68 – ''Calloselasma rhodostoma'' – NMR<br />
[[2pjg]], [[2pji]] -  Cr rhodostoxin (mutant) – NMR<br />
[[2pjg]], [[2pji]], [[2ljv]] -  Cr rhodostoxin (mutant) 1-68 – NMR<br />
[[3uci]], [[26qz]], [[4r5r]], [[4r5u]], [[4rqg]] - Cr rhodostoxin (mutant) 408-475<br />
[[2m75]], [[2m7f]], [[2m7h]] - Cr rhodostoxin (mutant) 408-475 – NMR<br />
[[1z1x]], [[1tej]] – Ec disintegrin – ''Echis carinatus''<br />
[[1z1x]], [[1tej]] – Ec disintegrin – ''Echis carinatus''<br />
[[1rmr]] – Ec schistatin<br />
[[1rmr]] – Ec schistatin<br />
[[6lsq]] – Ec echistatin<br />
[[1ro3]], [[2ech]] – Ec echistatin - NMR<br />
[[1ro3]], [[2ech]] – Ec echistatin - NMR<br />
[[1l3x]] – salmosin – ''Gloydius brevicaudus'' – NMR<br />
[[1l3x]] – salmosin – ''Gloydius brevicaudus'' – NMR<br />
[[1mpz]] – obtustatin – ''Macrovipera obtusa'' - NMR<br />
[[1mpz]] – obtustatin – ''Macrovipera obtusa'' - NMR<br />
[[1dem]] – dendrotoxin I – black mamba<br />
[[3c05]] – acostatin-α residues 48-109+acostatin-β residues 419-482 – copperhead<br />
[[1den]] - dendrotoxin I - NMR<br />
[[3dsl]] – bothropasin - Jararaca<br />
[[1dtk]] - dendrotoxin K- NMR<br />
[[2dw0]], [[2dw1]], [[2dw2]] – catrocollastatin – rattlesnake<br />
[[1dtx]] – α-dendrotoxin - Eastern green mamba<br />
[[2mop]], [[2mp5]] – bitistatin – African puff adder - NMR<br />
 
 
== References ==
<references/>
[[Category:Topic Page]]
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