Agrin: Difference between revisions
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<StructureSection load='' size='350' side='right' caption='Chicken agrin (PDB code [[3i70]]).' scene='41/417482/Cv/2'> | |||
__TOC__ | |||
== Function == | |||
[[Agrin]] (Agr) is involved in the embryogenesis of the neuromuscular junction. It is involved in the aggregation of acetylcholine receptors. | [[Agrin]] (Agr) is involved in the embryogenesis of the neuromuscular junction. It is involved in the aggregation of acetylcholine receptors. <ref>PMID:7852425</ref> | ||
== Relevance == | |||
Agr is an inducer of mammalian heart regeneration<ref>PMID:28581497</ref>. | |||
== Disease == | |||
Agr is overexpressed in brains of Alzheimer Disease patients. Agr is associated with myasthenic syndrome. | |||
== Structural highlights == | |||
Agr N-terminal domain binds laminin. The C-terminal of Agr has 3 laminin-like globular domains (LMB) G1-G3 and 4 epidermal growth factor-like domains. Agr binds heparan sulfate post-translationally. Other Agr domains are: Kazal type serine protease inhibitor. | |||
== 3D Structures of Agrin == | == 3D Structures of Agrin == | ||
[[Agrin 3D structures]] | |||
</StructureSection> | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 11:05, 3 March 2019
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