1mrp: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(20 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1mrp.gif|left|200px]]<br />
<applet load="1mrp" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1mrp, resolution 1.6&Aring;" />
'''FERRIC-BINDING PROTEIN FROM HAEMOPHILUS INFLUENZAE'''<br />


==Overview==
==FERRIC-BINDING PROTEIN FROM HAEMOPHILUS INFLUENZAE==
The first crystal structure of the iron-transporter ferric ion-binding, protein from Haemophilus influenzae (hFBP), at 1.6 A resolution, reveals, the structural basis for iron uptake and transport required by several, important bacterial pathogens. Paradoxically, although hFBP belongs to a, protein superfamily which includes human transferrin, iron binding in hFBP, and transferrin appears to have developed independently by convergent, evolution. Structural comparison of hFBP with other prokaryotic, periplasmic transport proteins and the eukaryotic transferrins suggests, that these proteins are related by divergent evolution from an, anion-binding common ancestor, not from an iron-binding ancestor. The iron, binding site of hFBP incorporates a water and an exogenous phosphate ion, as iron ... [[http://ispc.weizmann.ac.il/pmbin/getpm?9360608 (full description)]]
<StructureSection load='1mrp' size='340' side='right'caption='[[1mrp]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1mrp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MRP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mrp OCA], [https://pdbe.org/1mrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mrp RCSB], [https://www.ebi.ac.uk/pdbsum/1mrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mrp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FBPA_HAEIN FBPA_HAEIN] Part of the ABC transporter complex FbpABC (TC 3.A.1.10.1) involved in Fe(3+) ions import. This protein specifically binds Fe(3+) and is involved in its transmembrane transport (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mr/1mrp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mrp ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1MRP is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]] with FE and PO4 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Sites: FE and PO4. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1MRP OCA]].
*[[Ferric-binding protein|Ferric-binding protein]]
 
__TOC__
==Reference==
</StructureSection>
Structure of Haemophilus influenzae Fe(+3)-binding protein reveals convergent evolution within a superfamily., Bruns CM, Nowalk AJ, Arvai AS, McTigue MA, Vaughan KG, Mietzner TA, McRee DE, Nat Struct Biol. 1997 Nov;4(11):919-24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9360608 9360608]
[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arvai, A.S.]]
[[Category: Arvai AS]]
[[Category: Bruns, C.M.]]
[[Category: Bruns CM]]
[[Category: Mcree, D.E.]]
[[Category: Mcree DE]]
[[Category: Mctigue, M.A.]]
[[Category: Mctigue MA]]
[[Category: Mietzner, T.A.]]
[[Category: Mietzner TA]]
[[Category: Nowalk, A.J.]]
[[Category: Nowalk AJ]]
[[Category: Vaughan, K.G.]]
[[Category: Vaughan KG]]
[[Category: FE]]
[[Category: PO4]]
[[Category: ferric iron binding protein]]
[[Category: iron transport]]
[[Category: periplasmic binding protein]]
[[Category: transferrin superfamily]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:19:20 2007''

Latest revision as of 07:47, 14 February 2024

FERRIC-BINDING PROTEIN FROM HAEMOPHILUS INFLUENZAE

1mrp, resolution 1.60Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1mrp&oldid=4051813"