2rh9: Difference between revisions

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New page: left|200px<br /><applet load="2rh9" size="350" color="white" frame="true" align="right" spinBox="true" caption="2rh9, resolution 1.70Å" /> '''Tryptophan synthase ...
 
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[[Image:2rh9.jpg|left|200px]]<br /><applet load="2rh9" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2rh9, resolution 1.70&Aring;" />
'''Tryptophan synthase complexed with IGP, internal aldimine, pH 9.0'''<br />


==About this Structure==
==Tryptophan synthase complexed with IGP, internal aldimine, pH 9.0==
2RH9 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium] with <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=IGP:'>IGP</scene> and <scene name='pdbligand=PLP:'>PLP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RH9 OCA].
<StructureSection load='2rh9' size='340' side='right'caption='[[2rh9]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
[[Category: Protein complex]]
== Structural highlights ==
[[Category: Salmonella typhimurium]]
<table><tr><td colspan='2'>[[2rh9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RH9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RH9 FirstGlance]. <br>
[[Category: Tryptophan synthase]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
[[Category: Barends, T.R.M.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IGP:INDOLE-3-GLYCEROL+PHOSPHATE'>IGP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
[[Category: Kulik, V.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rh9 OCA], [https://pdbe.org/2rh9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rh9 RCSB], [https://www.ebi.ac.uk/pdbsum/2rh9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rh9 ProSAT]</span></td></tr>
[[Category: Schlichting, I.]]
</table>
[[Category: IGP]]
== Function ==
[[Category: NA]]
[https://www.uniprot.org/uniprot/TRPA_SALTY TRPA_SALTY] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
[[Category: PLP]]
== Evolutionary Conservation ==
[[Category: allosteric enzyme]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: amino-acid biosynthesis]]
Check<jmol>
[[Category: aminoacid biosynthesis]]
  <jmolCheckbox>
[[Category: aromatic amino acid biosynthesis]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rh/2rh9_consurf.spt"</scriptWhenChecked>
[[Category: carbon-oxygen lyase]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
[[Category: lyase]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: pyridoxal phosphate]]
  </jmolCheckbox>
[[Category: tryptophan biosynthesis]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rh9 ConSurf].
<div style="clear:both"></div>


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:24:32 2008''
==See Also==
*[[Tryptophan synthase 3D structures|Tryptophan synthase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
[[Category: Barends TRM]]
[[Category: Kulik V]]
[[Category: Schlichting I]]
Retrieved from "https://proteopedia.org/2rh9"