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[[Image:1deq.png|left|200px]]


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==THE CRYSTAL STRUCTURE OF MODIFIED BOVINE FIBRINOGEN (AT ~4 ANGSTROM RESOLUTION)==
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<StructureSection load='1deq' size='340' side='right'caption='[[1deq]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1deq]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DEQ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1deq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1deq OCA], [https://pdbe.org/1deq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1deq RCSB], [https://www.ebi.ac.uk/pdbsum/1deq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1deq ProSAT]</span></td></tr>
{{STRUCTURE_1deq|  PDB=1deq  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/FIBA_BOVIN FIBA_BOVIN] Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/de/1deq_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1deq ConSurf].
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== Publication Abstract from PubMed ==
Here we report the crystal structure at approximately 4-A resolution of a selectively proteolyzed bovine fibrinogen. This key component in hemostasis is an elongated 340-kDa glycoprotein in the plasma that upon activation by thrombin self-assembles to form the fibrin clot. The crystals are unusual because they are made up of end-to-end bonded molecules that form flexible filaments. We have visualized the entire coiled-coil region of the molecule, which has a planar sigmoidal shape. The primary polymerization receptor pockets at the ends of the molecule face the same way throughout the end-to-end bonded filaments, and based on this conformation, we have developed an improved model of the two-stranded protofibril that is the basic building block in fibrin. Near the middle of the coiled-coil region, the plasmin-sensitive segment is a hinge about which the molecule adopts different conformations. This segment also includes the boundary between the three- and four-stranded portions of the coiled coil, indicating the location on the backbone that anchors the extended flexible Aalpha arm. We suggest that a flexible branch point in the molecule may help accommodate variability in the structure of the fibrin clot.


===THE CRYSTAL STRUCTURE OF MODIFIED BOVINE FIBRINOGEN (AT ~4 ANGSTROM RESOLUTION)===
The crystal structure of modified bovine fibrinogen.,Brown JH, Volkmann N, Jun G, Henschen-Edman AH, Cohen C Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):85-90. PMID:10618375<ref>PMID:10618375</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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(as it appears on PubMed at http://www.pubmed.gov), where 10618375 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10618375}}
 
==About this Structure==
[[1deq]] is a 14 chain structure of [[Fibrinogen]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DEQ OCA].


==See Also==
==See Also==
*[[Fibrinogen]]
*[[Fibrinogen|Fibrinogen]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:10618375</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Brown, J H.]]
[[Category: Large Structures]]
[[Category: Cohen, C.]]
[[Category: Brown JH]]
[[Category: Henschen-Edman, A H.]]
[[Category: Cohen C]]
[[Category: Jun, G.]]
[[Category: Henschen-Edman AH]]
[[Category: Volkmann, N.]]
[[Category: Jun G]]
[[Category: Blood clotting]]
[[Category: Volkmann N]]
[[Category: Coiled-coil]]
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