1vit: Difference between revisions

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[[Image:1vit.png|left|200px]]


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==THROMBIN:HIRUDIN 51-65 COMPLEX==
The line below this paragraph, containing "STRUCTURE_1vit", creates the "Structure Box" on the page.
<StructureSection load='1vit' size='340' side='right'caption='[[1vit]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1vit]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VIT FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
{{STRUCTURE_1vit|  PDB=1vit  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vit OCA], [https://pdbe.org/1vit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vit RCSB], [https://www.ebi.ac.uk/pdbsum/1vit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vit ProSAT]</span></td></tr>
 
</table>
===THROMBIN:HIRUDIN 51-65 COMPLEX===
== Function ==
 
[https://www.uniprot.org/uniprot/THRB_BOVIN THRB_BOVIN] Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).
 
== Evolutionary Conservation ==
<!--
[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_15299666}}, adds the Publication Abstract to the page
Check<jmol>
(as it appears on PubMed at http://www.pubmed.gov), where 15299666 is the PubMed ID number.
  <jmolCheckbox>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vi/1vit_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_15299666}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
[[1vit]] is a 7 chain structure of [[Hirudin]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VIT OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vit ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Hirudin]]
*[[Hirudin 3D structures|Hirudin 3D structures]]
 
*[[Thrombin 3D Structures|Thrombin 3D Structures]]
==Reference==
__TOC__
<ref group="xtra">PMID:15299666</ref><references group="xtra"/>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Thrombin]]
[[Category: Large Structures]]
[[Category: Edwards, B F.P.]]
[[Category: Edwards BFP]]
[[Category: Vitali, J.]]
[[Category: Vitali J]]
[[Category: Blood coagulation]]
[[Category: Hydrolase]]
[[Category: Serine protease]]
Retrieved from "https://proteopedia.org/1vit"