2aka: Difference between revisions

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[[Image:2aka.png|left|200px]]


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==Structure of the nucleotide-free myosin II motor domain from Dictyostelium discoideum fused to the GTPase domain of dynamin 1 from Rattus norvegicus==
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<StructureSection load='2aka' size='340' side='right'caption='[[2aka]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2aka]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AKA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aka OCA], [https://pdbe.org/2aka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aka RCSB], [https://www.ebi.ac.uk/pdbsum/2aka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aka ProSAT]</span></td></tr>
{{STRUCTURE_2aka|  PDB=2aka  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/DYN1_RAT DYN1_RAT] Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ak/2aka_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aka ConSurf].
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== Publication Abstract from PubMed ==
Here, we present the 1.9-A crystal structure of the nucleotide-free GTPase domain of dynamin 1 from Rattus norvegicus. The structure corresponds to an extended form of the canonical GTPase fold observed in Ras proteins. Both nucleotide-binding switch motifs are well resolved, adopting conformations that closely resemble a GTP-bound state not previously observed for nucleotide-free GTPases. Two highly conserved arginines, Arg-66 and Arg-67, greatly restrict the mobility of switch I and are ideally positioned to relay information about the nucleotide state to other parts of the protein. Our results support a model in which switch I residue Arg-59 gates GTP binding in an assembly-dependent manner and the GTPase effector domain functions as an assembly-dependent GTPase activating protein in the fashion of RGS-type GAPs.


===Structure of the nucleotide-free myosin II motor domain from Dictyostelium discoideum fused to the GTPase domain of dynamin 1 from Rattus norvegicus===
Crystal structure of the GTPase domain of rat dynamin 1.,Reubold TF, Eschenburg S, Becker A, Leonard M, Schmid SL, Vallee RB, Kull FJ, Manstein DJ Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13093-8. Epub 2005 Sep 2. PMID:16141317<ref>PMID:16141317</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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{{ABSTRACT_PUBMED_16141317}}
 
==About this Structure==
[[2aka]] is a 3 chain structure of [[Myosin]] with sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AKA OCA].


==See Also==
==See Also==
*[[Myosin]]
*[[Myosin 3D Structures|Myosin 3D Structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:16141317</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Dictyostelium discoideum]]
[[Category: Dictyostelium discoideum]]
[[Category: Dynamin GTPase]]
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Becker, A.]]
[[Category: Becker A]]
[[Category: Eschenburg, S.]]
[[Category: Eschenburg S]]
[[Category: Kull, F J.]]
[[Category: Kull FJ]]
[[Category: Leonard, M.]]
[[Category: Leonard M]]
[[Category: Manstein, D J.]]
[[Category: Manstein DJ]]
[[Category: Reubold, T F.]]
[[Category: Reubold TF]]
[[Category: Schmid, S L.]]
[[Category: Schmid SL]]
[[Category: Vallee, R B.]]
[[Category: Vallee RB]]
[[Category: Contractile protein]]
[[Category: Dynamin]]
[[Category: Fusion protein]]
[[Category: Gtpase domain]]
[[Category: Myosin]]
Retrieved from "https://proteopedia.org/2aka"