1lud: Difference between revisions

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[[Image:1lud.png|left|200px]]


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==SOLUTION STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETHOPRIM AND NADPH, 24 STRUCTURES==
The line below this paragraph, containing "STRUCTURE_1lud", creates the "Structure Box" on the page.
<StructureSection load='1lud' size='340' side='right'caption='[[1lud]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1lud]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LUD FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=TRR:2,4-DIAMINO-5-(3,4,5-TRIMETHOXY-BENZYL)-PYRIMIDIN-1-IUM'>TRR</scene></td></tr>
{{STRUCTURE_1lud|  PDB=1lud  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lud OCA], [https://pdbe.org/1lud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lud RCSB], [https://www.ebi.ac.uk/pdbsum/1lud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lud ProSAT]</span></td></tr>
 
</table>
===SOLUTION STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETHOPRIM AND NADPH, 24 STRUCTURES===
== Function ==
 
[https://www.uniprot.org/uniprot/DYR_LACCA DYR_LACCA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
[[1lud]] is a 1 chain structure of [[Dihydrofolate reductase]] with sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LUD OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lu/1lud_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lud ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Dihydrofolate reductase]]
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:12449420</ref><references group="xtra"/>
[[Category: Lacticaseibacillus casei]]
[[Category: Dihydrofolate reductase]]
[[Category: Large Structures]]
[[Category: Lactobacillus casei]]
[[Category: Birdsall B]]
[[Category: Birdsall, B.]]
[[Category: Feeney J]]
[[Category: Feeney, J.]]
[[Category: Kelly G]]
[[Category: Kelly, G.]]
[[Category: Polshakov VI]]
[[Category: Polshakov, V I.]]
[[Category: Smirnov EG]]
[[Category: Smirnov, E G.]]
[[Category: Dhfr]]
[[Category: Inhibitor/enzyme complex]]
[[Category: Oxidoreductase]]
Retrieved from "https://proteopedia.org/1lud"