1a0t: Difference between revisions

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[[Image:1a0t.png|left|200px]]


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==SUCROSE-SPECIFIC PORIN, WITH BOUND SUCROSE MOLECULES==
The line below this paragraph, containing "STRUCTURE_1a0t", creates the "Structure Box" on the page.
<StructureSection load='1a0t' size='340' side='right'caption='[[1a0t]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1a0t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A0T FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FRU:FRUCTOSE'>FRU</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900003:sucrose'>PRD_900003</scene></td></tr>
{{STRUCTURE_1a0t|  PDB=1a0t  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a0t OCA], [https://pdbe.org/1a0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a0t RCSB], [https://www.ebi.ac.uk/pdbsum/1a0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a0t ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SCRY_SALTM SCRY_SALTM] Porin for sucrose uptake.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a0/1a0t_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a0t ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The X-ray structure of a sucrose-specific porin (ScrY) from Salmonella typhimurium has been determined by multiple isomorphous replacement at 2.4 A resolution both in its uncomplexed form and with bound sucrose. ScrY is a noncrystallographic trimer of identical subunits, each with 413 structurally well-defined amino acids. A monomer is built up of 18 anti-parallel beta-strands surrounding a hydrophilic pore, with a topology closely similar to that of maltoporin. Two non-overlapping sucrose-binding sites were identified in difference Fourier maps. The higher permeability for sucrose of ScrY as compared to maltoporin is mainly accounted for by differences in their pore-lining residues.


===SUCROSE-SPECIFIC PORIN, WITH BOUND SUCROSE MOLECULES===
Structure of the sucrose-specific porin ScrY from Salmonella typhimurium and its complex with sucrose.,Forst D, Welte W, Wacker T, Diederichs K Nat Struct Biol. 1998 Jan;5(1):37-46. PMID:9437428<ref>PMID:9437428</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_9437428}}, adds the Publication Abstract to the page
<div class="pdbe-citations 1a0t" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 9437428 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9437428}}
 
==About this Structure==
[[1a0t]] is a 3 chain structure of [[Porin]] with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A0T OCA].


==See Also==
==See Also==
*[[Porin]]
*[[Porin 3D structures|Porin 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:9437428</ref><references group="xtra"/>
__TOC__
[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
</StructureSection>
[[Category: Diederichs, K.]]
[[Category: Large Structures]]
[[Category: Welte, W.]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
[[Category: Outer membrane protein]]
[[Category: Diederichs K]]
[[Category: Porin]]
[[Category: Welte W]]

Latest revision as of 10:44, 2 August 2023

SUCROSE-SPECIFIC PORIN, WITH BOUND SUCROSE MOLECULES

1a0t, resolution 2.40Å

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