2f2b: Difference between revisions

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[[Image:2f2b.png|left|200px]]


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==Crystal structure of integral membrane protein Aquaporin AqpM at 1.68A resolution==
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<StructureSection load='2f2b' size='340' side='right'caption='[[2f2b]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2f2b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_marburgensis_str._Marburg Methanothermobacter marburgensis str. Marburg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F2B FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
{{STRUCTURE_2f2b|  PDB=2f2b  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f2b OCA], [https://pdbe.org/2f2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f2b RCSB], [https://www.ebi.ac.uk/pdbsum/2f2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f2b ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AQPM_METTM AQPM_METTM] Channel that permits osmotically driven movement of water in both directions. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Exhibits also a transient but reproducible increase in the initial glycerol flux.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
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    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f2b ConSurf].
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== Publication Abstract from PubMed ==
To explore the structural basis of the unique selectivity spectrum and conductance of the transmembrane channel protein AqpM from the archaeon Methanothermobacter marburgensis, we determined the structure of AqpM to 1.68-A resolution by x-ray crystallography. The structure establishes AqpM as being in a unique subdivision between the two major subdivisions of aquaporins, the water-selective aquaporins, and the water-plus-glycerol-conducting aquaglyceroporins. In AqpM, isoleucine replaces a key histidine residue found in the lumen of water channels, which becomes a glycine residue in aquaglyceroporins. As a result of this and other side-chain substituents in the walls of the channel, the channel is intermediate in size and exhibits differentially tuned electrostatics when compared with the other subfamilies.


===Crystal structure of integral membrane protein Aquaporin AqpM at 1.68A resolution===
Structural basis for conductance by the archaeal aquaporin AqpM at 1.68 A.,Lee JK, Kozono D, Remis J, Kitagawa Y, Agre P, Stroud RM Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18932-7. Epub 2005 Dec 16. PMID:16361443<ref>PMID:16361443</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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{{ABSTRACT_PUBMED_16361443}}
 
==About this Structure==
[[2f2b]] is a 1 chain structure of [[Aquaporin]] with sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_marburgensis_str._marburg Methanothermobacter marburgensis str. marburg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2B OCA].


==See Also==
==See Also==
*[[Aquaporin]]
*[[Aquaporin 3D structures|Aquaporin 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:16361443</ref><references group="xtra"/>
__TOC__
[[Category: Methanothermobacter marburgensis str. marburg]]
</StructureSection>
[[Category: Agre, P.]]
[[Category: Large Structures]]
[[Category: CSMP, Center for Structures of Membrane Proteins.]]
[[Category: Methanothermobacter marburgensis str. Marburg]]
[[Category: Kitagawa, Y.]]
[[Category: Agre P]]
[[Category: Kozono, D.]]
[[Category: Kitagawa Y]]
[[Category: Lee, J K.]]
[[Category: Kozono D]]
[[Category: Remis, J.]]
[[Category: Lee JK]]
[[Category: Stroud, R M.]]
[[Category: Remis J]]
[[Category: Center for structures of membrane protein]]
[[Category: Stroud RM]]
[[Category: Channel]]
[[Category: Csmp]]
[[Category: Integral membrane protein]]
[[Category: Protein]]
[[Category: Protein structure initiative]]
[[Category: Psi-2]]
[[Category: Structural genomic]]
Retrieved from "https://proteopedia.org/2f2b"