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New page: left|200px<br /><applet load="2yxe" size="350" color="white" frame="true" align="right" spinBox="true" caption="2yxe, resolution 2.00Å" /> '''Crystal structure of...
 
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[[Image:2yxe.gif|left|200px]]<br /><applet load="2yxe" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2yxe, resolution 2.00&Aring;" />
'''Crystal structure of L-isoaspartyl protein carboxyl methyltranferase'''<br />


==About this Structure==
==Crystal structure of L-isoaspartyl protein carboxyl methyltranferase==
2YXE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii] with <scene name='pdbligand=ACT:'>ACT</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Protein-L-isoaspartate(D-aspartate)_O-methyltransferase Protein-L-isoaspartate(D-aspartate) O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.77 2.1.1.77] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXE OCA].
<StructureSection load='2yxe' size='340' side='right'caption='[[2yxe]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
[[Category: Methanocaldococcus jannaschii]]
== Structural highlights ==
[[Category: Protein-L-isoaspartate(D-aspartate) O-methyltransferase]]
<table><tr><td colspan='2'>[[2yxe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii_DSM_2661 Methanocaldococcus jannaschii DSM 2661]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YXE FirstGlance]. <br>
[[Category: Single protein]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
[[Category: Bessho, Y.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
[[Category: Padmanabhan, B.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yxe OCA], [https://pdbe.org/2yxe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yxe RCSB], [https://www.ebi.ac.uk/pdbsum/2yxe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yxe ProSAT], [https://www.topsan.org/Proteins/RSGI/2yxe TOPSAN]</span></td></tr>
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
</table>
[[Category: Yokoyama, S.]]
== Function ==
[[Category: ACT]]
[https://www.uniprot.org/uniprot/PIMT_METJA PIMT_METJA] Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins (By similarity).
[[Category: alpha/beta/alpha sandwich structure]]
== Evolutionary Conservation ==
[[Category: national project on protein structural and functional analyses]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: nppsfa]]
Check<jmol>
[[Category: riken structural genomics/proteomics initiative]]
  <jmolCheckbox>
[[Category: rossman-type fold]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yx/2yxe_consurf.spt"</scriptWhenChecked>
[[Category: rsgi]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: structural genomics]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: transferase]]
  </jmolCheckbox>
 
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yxe ConSurf].
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:39:21 2008''
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Methanocaldococcus jannaschii DSM 2661]]
[[Category: Bessho Y]]
[[Category: Padmanabhan B]]
[[Category: Yokoyama S]]

Latest revision as of 09:09, 25 October 2023

Crystal structure of L-isoaspartyl protein carboxyl methyltranferase

2yxe, resolution 2.00Å

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