2iww: Difference between revisions

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[[Image:2iww.png|left|200px]]


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==Structure of the monomeric outer membrane porin OmpG in the open and closed conformation==
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<StructureSection load='2iww' size='340' side='right'caption='[[2iww]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2iww]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IWW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene></td></tr>
{{STRUCTURE_2iww|  PDB=2iww  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iww OCA], [https://pdbe.org/2iww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iww RCSB], [https://www.ebi.ac.uk/pdbsum/2iww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iww ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/OMPG_ECOLI OMPG_ECOLI] Forms channels functionally larger than those of classical porins.<ref>PMID:11758943</ref>  May act as a regulator of the RCS-phosphorelay signal transduction pathway.<ref>PMID:11758943</ref>
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== Publication Abstract from PubMed ==
OmpG, a monomeric pore-forming protein from Escherichia coli outer membranes, was refolded from inclusion bodies and crystallized in two different conformations. The OmpG channel is a 14-stranded beta-barrel, with short periplasmic turns and seven extracellular loops. Crystals grown at neutral pH show the channel in the open state at 2.3 A resolution. In the 2.7 A structure of crystals grown at pH 5.6, the pore is blocked by loop 6, which folds across the channel. The rearrangement of loop 6 appears to be triggered by a pair of histidine residues, which repel one another at acidic pH, resulting in the breakage of neighbouring H-bonds and a lengthening of loop 6 from 10 to 17 residues. A total of 151 ordered LDAO detergent molecules were found in the 2.3 A structure, mostly on the hydrophobic outer surface of OmpG, mimicking the outer membrane lipid bilayer, with three LDAO molecules in the open pore. In the 2.7 A structure, OmpG binds one OG and one glucose molecule as sugar substrates in the closed pore.


===STRUCTURE OF THE MONOMERIC OUTER MEMBRANE PORIN OMPG IN THE OPEN AND CLOSED CONFORMATION===
Structure of the monomeric outer-membrane porin OmpG in the open and closed conformation.,Yildiz O, Vinothkumar KR, Goswami P, Kuhlbrandt W EMBO J. 2006 Aug 9;25(15):3702-13. Epub 2006 Aug 3. PMID:16888630<ref>PMID:16888630</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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{{ABSTRACT_PUBMED_16888630}}
 
==About this Structure==
[[2iww]] is a 2 chain structure of [[Porin]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IWW OCA].


==See Also==
==See Also==
*[[Porin]]
*[[Porin 3D structures|Porin 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:16888630</ref><references group="xtra"/>
__TOC__
[[Category: Escherichia coli]]
</StructureSection>
[[Category: Goswami, P.]]
[[Category: Escherichia coli K-12]]
[[Category: Kuehlbrandt, W.]]
[[Category: Large Structures]]
[[Category: Vinothkumar, K R.]]
[[Category: Goswami P]]
[[Category: Yildiz, O.]]
[[Category: Kuehlbrandt W]]
[[Category: Ion channel]]
[[Category: Vinothkumar KR]]
[[Category: Ion transport]]
[[Category: Yildiz O]]
[[Category: Membrane]]
[[Category: Outer membrane]]
[[Category: Porin]]
[[Category: Transmembrane]]
[[Category: Transport]]
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