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[[Image:2rf0.jpg|left|200px]]<br /><applet load="2rf0" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2rf0, resolution 2.00&Aring;" />
'''Crystal structure of human mixed lineage kinase MAP3K10 SH3 domain'''<br />


==About this Structure==
==Crystal structure of human mixed lineage kinase MAP3K10 SH3 domain==
2RF0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=EDO:'>EDO</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase_kinase Mitogen-activated protein kinase kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.25 2.7.11.25] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RF0 OCA].  
<StructureSection load='2rf0' size='340' side='right'caption='[[2rf0]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2rf0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RF0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RF0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rf0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rf0 OCA], [https://pdbe.org/2rf0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rf0 RCSB], [https://www.ebi.ac.uk/pdbsum/2rf0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rf0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/M3K10_HUMAN M3K10_HUMAN] Activates the JUN N-terminal pathway (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rf/2rf0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rf0 ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Mitogen-activated protein kinase kinase kinase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith, C.H.]]
[[Category: Berridge G]]
[[Category: Berridge, G.]]
[[Category: Edwards AM]]
[[Category: Delft, F.von.]]
[[Category: Elkins J]]
[[Category: Edwards, A.M.]]
[[Category: Eswaran J]]
[[Category: Elkins, J.]]
[[Category: Keates T]]
[[Category: Eswaran, J.]]
[[Category: Knapp S]]
[[Category: Keates, T.]]
[[Category: Pike ACW]]
[[Category: Knapp, S.]]
[[Category: Savitsky P]]
[[Category: Pike, A.C.W.]]
[[Category: Sundstrom M]]
[[Category: SGC, Structural.Genomics.Consortium.]]
[[Category: Ugochukwu E]]
[[Category: Savitsky, P.]]
[[Category: Weigelt J]]
[[Category: Sundstrom, M.]]
[[Category: Von Delft F]]
[[Category: Ugochukwu, E.]]
[[Category: Weigelt, J.]]
[[Category: EDO]]
[[Category: atp-binding]]
[[Category: map3k10]]
[[Category: mkn28]]
[[Category: mlk2]]
[[Category: nucleotide-binding]]
[[Category: phosphorylation]]
[[Category: serine/threonine-protein kinase]]
[[Category: sgc]]
[[Category: sh3 domain]]
[[Category: structural genomics]]
[[Category: structural genomics consortium]]
[[Category: tkl kinase]]
[[Category: transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:45:10 2008''
Retrieved from "https://proteopedia.org/2rf0"