2fyp: Difference between revisions

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[[Image:2fyp.png|left|200px]]


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==GRP94 in complex with the novel HSP90 Inhibitor Radester amine==
The line below this paragraph, containing "STRUCTURE_2fyp", creates the "Structure Box" on the page.
<StructureSection load='2fyp' size='340' side='right'caption='[[2fyp]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2fyp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FYP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FYP FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=RDE:2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL+5-CHLORO-2,4-DIHYDROXYBENZOATE'>RDE</scene></td></tr>
{{STRUCTURE_2fyp|  PDB=2fyp  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fyp OCA], [https://pdbe.org/2fyp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fyp RCSB], [https://www.ebi.ac.uk/pdbsum/2fyp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fyp ProSAT]</span></td></tr>
 
</table>
===GRP94 in complex with the novel HSP90 Inhibitor Radester amine===
== Function ==
 
[https://www.uniprot.org/uniprot/ENPL_CANLF ENPL_CANLF] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
[[2fyp]] is a 2 chain structure of [[Endoplasmin]] with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FYP OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fy/2fyp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fyp ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Endoplasmin]]
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
__TOC__
</StructureSection>
[[Category: Canis lupus familiaris]]
[[Category: Canis lupus familiaris]]
[[Category: Gewirth, D T.]]
[[Category: Large Structures]]
[[Category: Immormino, R M.]]
[[Category: Gewirth DT]]
[[Category: Chaperone]]
[[Category: Immormino RM]]
[[Category: Geldanamycin]]
[[Category: Grp94]]
[[Category: Hsp82]]
[[Category: Hsp90]]
[[Category: Htpg]]
[[Category: Ligand]]
[[Category: Radamide]]
[[Category: Radester]]
[[Category: Radicicol]]
Retrieved from "https://proteopedia.org/2fyp"