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New page: left|200px<br /><applet load="2qfi" size="350" color="white" frame="true" align="right" spinBox="true" caption="2qfi, resolution 3.80Å" /> '''Structure of the zin...
 
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[[Image:2qfi.gif|left|200px]]<br /><applet load="2qfi" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2qfi, resolution 3.80&Aring;" />
'''Structure of the zinc transporter YiiP'''<br />


==Overview==
==Structure of the zinc transporter YiiP==
YiiP is a membrane transporter that catalyzes Zn2+/H+ exchange across the, inner membrane of Escherichia coli. Mammalian homologs of YiiP play, critical roles in zinc homeostasis and cell signaling. Here, we report the, x-ray structure of YiiP in complex with zinc at 3.8 angstrom resolution., YiiP is a homodimer held together in a parallel orientation through four, Zn2+ ions at the interface of the cytoplasmic domains, whereas the two, transmembrane domains swing out to yield a Y-shaped structure. In each, protomer, the cytoplasmic domain adopts a metallochaperone-like protein, fold; the transmembrane domain features a bundle of six transmembrane, helices and a tetrahedral Zn2+ binding site located in a cavity that is, open to both the membrane outer leaflet and the periplasm.
<StructureSection load='2qfi' size='340' side='right'caption='[[2qfi]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[2qfi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QFI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QFI FirstGlance]. <br>
2QFI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QFI OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qfi OCA], [https://pdbe.org/2qfi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qfi RCSB], [https://www.ebi.ac.uk/pdbsum/2qfi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qfi ProSAT]</span></td></tr>
Structure of the zinc transporter YiiP., Lu M, Fu D, Science. 2007 Sep 21;317(5845):1746-8. Epub 2007 Aug 23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17717154 17717154]
</table>
== Function ==
[https://www.uniprot.org/uniprot/FIEF_ECOLI FIEF_ECOLI] Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton-dependent manner.<ref>PMID:15549269</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qf/2qfi_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qfi ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Lu, M.]]
[[Category: Lu M]]
[[Category: ZN]]
[[Category: transport protein]]
[[Category: zinc transporter]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:53:53 2008''

Latest revision as of 09:15, 21 February 2024

Structure of the zinc transporter YiiP

2qfi, resolution 3.80Å

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