TATA-Binding Protein: Difference between revisions

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[[Image:1tbp.png|left|200px|thumb|Crystal Structure of yeast TATA-binding protein, [[1tbp]]]]
<StructureSection load='1tgh' size='350' side='right' scene='' caption='Human TATA-binding protein complex with DNA TATA box (PDB code [[1tgh]])'>
{{STRUCTURE_1tbp| PDB=1tbp | SIZE=300| SCENE=TATA-Binding_Protein/Cv/1 |right|CAPTION=TATA-binding protein, [[1tbp]] }}
== Function ==
[[TATA-Binding Protein]] (TBP) binds to TATA box in DNA and is part of the RNA polymerase II transcription complex.  The transcription factor proteins are named TFIIA to TFIIH. TBP is part of TFIID. Its interaction with DNA initiates the DNA strands separation<ref>PMID:7565278</ref>.  Called the <scene name='TATA-Binding_Protein/Tata_box/3'> TATA box</scene> to represent its thymine-adenine-thymine-adenine-adenine (TATAA) nucleotide motif.  See also<br />
* [[Transcription and RNA Processing]]<br />
* [[Yeast TATA Binding Protein]].


[[TATA-Binding Protein]] (TBP) binds to TATA box in DNA and is part of the RNA polymerase II transcription complex.  The transcription factor proteins are named TFIIA to TFIIH.  TBP is part of TFIID.  Its interaction with DNA initiates the DNA strands separation. The images at the left and at the right correspond to one representative TBP, ''i.e.'' the crystal structure of yeast TATA-binding protein ([[1tbp]]).
{{TOC limit|limit=2}}
== 3D Structures of TATA-binding protein ==
=== TBP ===
[[2z8u]] – TBP – ''Methanococcus janaschii''<br />
[[1pcz]] – PwTBP - ''Pyrococcus woesei''<br />
[[1vok]] – AtTBP - ''Arabidopsis thaliana''<br />
[[1tbp]] – yTBP - yeast<br />
[[1mp9]] – TBP – ''Sulfolobus acidocaldarius''<br />
=== TBP+DNA TATA ===
[[1ytb]] - yTBP + DNA TATA<br />
[[1cdw]] - hTBP core domain+ DNA TATA - human<br />
[[1tgh]] - hTBP + DNA TATA<br />
[[1qn5]], [[1qn6]], [[1qn7]], [[1qn8]], [[1qn9]], [[1qna]], [[1qnb]], [[1qnc]], [[1qne]], [[1qn3]], [[1qn4]] - AtTBP + DNA TATA <br />
=== TBP+DNA TATA+TFIIA ===
[[1rm1]] – yTBP+TFIIA α, β, γ chains+ DNA TATA <br />
[[1ytf]] - yTBP+TFIIA + DNA TATA<br />
[[1nh2]] – yTBP C-terminal+TFIIA α, β, γ chains+ DNA TATA<br />
[[1nvp]] - hTBP C-terminal+ TFIIA α, β, γ chains+ DNA TATA <br />
[[1jfi]] - hTBP C-terminal+ TFIIA NC2+ DNA TATA<br />
=== TBP+DNA TATA+TFIIB ===
[[1ngm]] - yTBP C-terminal+TFIIIB BRF1 subunit + DNA TATA<br />
[[1tba]] – yTBP core domain+TAFII230 fragment - NMR<br />
[[1c9b]] - hTBP C-terminal+TFIIBC+adenovirus major late promoter<br />
[[1vol]] – AtTBP+hTFIIB+DNA TATA<br />
[[1ais]], [[1du3]] - PwTBP N-terminal+ TFIIB C-terminal + DNA TATA <br />
[[1tba]] – yTBP core domain+TAFII230 fragment - NMR<br />
{{Clear}}
== Additional information ==
== Additional information ==


See: [[Transcription]] for additional Proteopedia resources
See: [[Transcription]] for additional Proteopedia resources


This page has some initial scenes, but could use expansion and creation of new scenes.
== Relevance ==
<applet load='1ytb' size='300' frame='true' align='right' caption='TATA-Binding Protein' scene='TATA-Binding_Protein/Tata-binding-protein/5' />
TBP is associated with aggregated proteins in several of the polyglutamine disorders like cerebellar ataxia<ref>PMID:15916858</ref>.


called the <scene name='TATA-Binding_Protein/Tata_box/3'> TATA box</scene> to represent its thymine-adenine-thymine-adenine-adenine (TATAA) nucleotide motif
== Structural highlights ==


<scene name='TATA-Binding_Protein/Lysine_and_arginine_phosphate/1'>interact with the phosphate groups</scene>
<scene name='TATA-Binding_Protein/Lysine_and_arginine_phosphate/1'>interact with the phosphate groups</scene>
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<scene name='TATA-Binding_Protein/Symmetrical/5'>two symmetrical halves</scene>.  
<scene name='TATA-Binding_Protein/Symmetrical/5'>two symmetrical halves</scene>.  
The interactions of <scene name='10/100866/Cv/2'>TBP with the DNA TATA box occurs with the minor groove of the DNA</scene>.  The DNA duplex is bent in a sharp angle and most interactions are non-polar of hydrophobic<ref>PMID:8757291</ref>.


{{Clear}}
{{Clear}}


== 3D Structures of TATA-binding protein ==
[[TATA-binding protein 3D structures]]
</StructureSection>
== References ==
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]
Retrieved from "https://proteopedia.org/TATA-Binding_Protein"