3px2: Difference between revisions

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[[Image:3px2.png|left|200px]]


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==Structure of TylM1 from Streptomyces fradiae H123N mutant in complex with SAH and dTDP-Quip3N==
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<StructureSection load='3px2' size='340' side='right'caption='[[3px2]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3px2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_fradiae Streptomyces fradiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PX2 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=T3Q:[(3R,4S,5S,6R)-4-AMINO-3,5-DIHYDROXY-6-METHYLOXAN-2-YL][HYDROXY-[[(2R,3S,5R)-3-HYDROXY-5-(5-METHYL-2,4-DIOXOPYRIMIDIN-1-YL)OXOLAN-2-YL]METHOXY]PHOSPHORYL]+HYDROGEN+PHOSPHATE'>T3Q</scene></td></tr>
{{STRUCTURE_3px2|  PDB=3px2  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3px2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3px2 OCA], [https://pdbe.org/3px2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3px2 RCSB], [https://www.ebi.ac.uk/pdbsum/3px2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3px2 ProSAT]</span></td></tr>
 
</table>
===Structure of TylM1 from Streptomyces fradiae H123N mutant in complex with SAH and dTDP-Quip3N===
== Function ==
 
[https://www.uniprot.org/uniprot/TYLM1_STRFR TYLM1_STRFR] S-adenosyl-L-methionine-dependent methyltransferase involved in the biosynthesis of mycaminose, an essential structural component of the macrolide antibiotic tylosin. Involved in the last step in mycaminose biosynthesis by mediating dimethylation of the hexose C-3' amino group.<ref>PMID:9031628</ref> <ref>PMID:12119032</ref> <ref>PMID:21142177</ref>  
 
== References ==
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<references/>
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[[Category: Large Structures]]
{{ABSTRACT_PUBMED_21142177}}
 
==About this Structure==
[[3px2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_fradiae Streptomyces fradiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PX2 OCA].  
 
==Reference==
<ref group="xtra">PMID:21142177</ref><references group="xtra"/>
[[Category: Streptomyces fradiae]]
[[Category: Streptomyces fradiae]]
[[Category: Carney, A E.]]
[[Category: Carney AE]]
[[Category: Holden, H M.]]
[[Category: Holden HM]]
[[Category: Dtdp-quip3n binding]]
[[Category: N-dimethyltransferase]]
[[Category: Sam binding]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/3px2"