3pur: Difference between revisions

Latest revision as of 13:33, 1 March 2024

CEKDM7A from C.Elegans, complex with D-2-HG

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[1] Lin H, Wang Y, Wang Y, Tian F, Pu P, Yu Y, Mao H, Yang Y, Wang P, Hu L, Lin Y, Liu Y, Xu Y, Chen CD. Coordinated regulation of active and repressive histone methylations by a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans. Cell Res. 2010 Aug;20(8):899-907. doi: 10.1038/cr.2010.84. Epub 2010 Jun 22. PMID:20567262 doi:10.1038/cr.2010.84

[2] Kleine-Kohlbrecher D, Christensen J, Vandamme J, Abarrategui I, Bak M, Tommerup N, Shi X, Gozani O, Rappsilber J, Salcini AE, Helin K. A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation. Mol Cell. 2010 Apr 23;38(2):165-78. doi: 10.1016/j.molcel.2010.03.002. Epub 2010 , Mar 25. PMID:20346720 doi:10.1016/j.molcel.2010.03.002

[3] Yang Y, Hu L, Wang P, Hou H, Lin Y, Liu Y, Li Z, Gong R, Feng X, Zhou L, Zhang W, Dong Y, Yang H, Lin H, Wang Y, Chen CD, Xu Y. Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans. Cell Res. 2010 Aug;20(8):886-98. Epub 2010 Jun 22. PMID:20567261 doi:10.1038/cr.2010.86

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-'''Unreleased structure'''
-The entry 3pur is ON HOLD  until Paper Publication
+==CEKDM7A from C.Elegans, complex with D-2-HG==
+<StructureSection load='3pur' size='340' side='right'caption='[[3pur]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-Authors: Yang, Y., Wang, P., Xu, W., Xu, Y.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3pur]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PUR FirstGlance]. <br>
-Description: CEKDM7A from C.Elegans, complex with D-2-HG
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2HG:(2R)-2-HYDROXYPENTANEDIOIC+ACID'>2HG</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pur OCA], [https://pdbe.org/3pur PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pur RCSB], [https://www.ebi.ac.uk/pdbsum/3pur PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pur ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/KDM7_CAEEL KDM7_CAEEL] Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code.<ref>PMID:20567262</ref> <ref>PMID:20346720</ref> <ref>PMID:20567261</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Caenorhabditis elegans]]
+[[Category: Large Structures]]
+[[Category: Wang P]]
+[[Category: Xu W]]
+[[Category: Xu Y]]
+[[Category: Yang Y]]

3pur: Difference between revisions

Latest revision as of 13:33, 1 March 2024

CEKDM7A from C.Elegans, complex with D-2-HG

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