3lqf: Difference between revisions

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[[Image:3lqf.png|left|200px]]


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==Crystal structure of the short-chain dehydrogenase Galactitol-Dehydrogenase (GatDH) of Rhodobacter sphaeroides in complex with NAD and erythritol==
The line below this paragraph, containing "STRUCTURE_3lqf", creates the "Structure Box" on the page.
<StructureSection load='3lqf' size='340' side='right'caption='[[3lqf]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3lqf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cereibacter_sphaeroides Cereibacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LQF FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MRY:MESO-ERYTHRITOL'>MRY</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
{{STRUCTURE_3lqf|  PDB=3lqf  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lqf OCA], [https://pdbe.org/3lqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lqf RCSB], [https://www.ebi.ac.uk/pdbsum/3lqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lqf ProSAT]</span></td></tr>
 
</table>
===Crystal structure of the short-chain dehydrogenase Galactitol-Dehydrogenase (GatDH) of Rhodobacter sphaeroides in complex with NAD and erythritol===
== Function ==
 
[https://www.uniprot.org/uniprot/GATDH_CERSP GATDH_CERSP] Catalyzes the interconversion of galactitol to the rare sugar L-tagatose (PubMed:7551050). Shows activity with a wide range of substrates, and catalyzes the oxidation of a variety of polyvalent aliphatic alcohols and polyols to the corresponding ketones and ketoses, respectively, and in the reverse reaction, it reduces ketones with high stereoselectivity yielding the corresponding S-configurated alcohols (PubMed:7551050, PubMed:15296184). Shows high activity with D-threitol, xylitol, 1,2-hexanediol, 1,2-pentanediol, 2-hexanol, L-erythrulose, D-ribulose and acetoin (PubMed:7551050). Specific for NAD(+) (PubMed:7551050).<ref>PMID:15296184</ref> <ref>PMID:7551050</ref>
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lq/3lqf_consurf.spt"</scriptWhenChecked>
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
[[3lqf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodobacter_sphaeroides Rhodobacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LQF OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lqf ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
<ref group="xtra">PMID:20410293</ref><references group="xtra"/>
<references/>
[[Category: Galactitol 2-dehydrogenase]]
__TOC__
[[Category: Rhodobacter sphaeroides]]
</StructureSection>
[[Category: Carius, Y.]]
[[Category: Cereibacter sphaeroides]]
[[Category: Christian, H.]]
[[Category: Large Structures]]
[[Category: Faust, A.]]
[[Category: Carius Y]]
[[Category: Giffhorn, F.]]
[[Category: Christian H]]
[[Category: Klink, B U.]]
[[Category: Faust A]]
[[Category: Kohring, G W.]]
[[Category: Giffhorn F]]
[[Category: Kornberger, P.]]
[[Category: Klink BU]]
[[Category: Scheidig, A J.]]
[[Category: Kohring GW]]
[[Category: Zander, U.]]
[[Category: Kornberger P]]
[[Category: Galactitol]]
[[Category: Scheidig AJ]]
[[Category: Oxidoreductase]]
[[Category: Zander U]]
[[Category: Rossmann fold]]
[[Category: Sdr]]
[[Category: Tagatose]]
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