3q7k: Difference between revisions
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New page: '''Unreleased structure''' The entry 3q7k is ON HOLD Authors: Lue, W., Du, J., Wacker, T., Gerbig-Smentek, E., Andrade, S. L. A., Einsle, O. Description: Formate Channel FocA from Salm... |
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The | ==Formate Channel FocA from Salmonella typhimurium== | ||
<StructureSection load='3q7k' size='340' side='right'caption='[[3q7k]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3q7k]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhi_str._CT18 Salmonella enterica subsp. enterica serovar Typhi str. CT18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q7K FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q7k OCA], [https://pdbe.org/3q7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q7k RCSB], [https://www.ebi.ac.uk/pdbsum/3q7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q7k ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q7CQU0_SALTY Q7CQU0_SALTY] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The formate transporter FocA was described to switch its mode of operation from a passive export channel at high external pH to a secondary active formate/H(+) importer at low pH. The crystal structure of Salmonella typhimurium FocA at pH 4.0 shows that this switch involves a major rearrangement of the amino termini of individual protomers in the pentameric channel. The amino-terminal helices open or block transport in a concerted, cooperative action that indicates how FocA is gated in a pH-dependent way. Electrophysiological studies show that the protein acts as a specific formate channel at pH 7.0 and that it closes upon a shift of pH to 5.1. | |||
pH-dependent gating in a FocA formate channel.,Lu W, Du J, Wacker T, Gerbig-Smentek E, Andrade SL, Einsle O Science. 2011 Apr 15;332(6027):352-4. PMID:21493860<ref>PMID:21493860</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 3q7k" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Salmonella enterica subsp. enterica serovar Typhi str. CT18]] | |||
[[Category: Andrade SLA]] | |||
[[Category: Du J]] | |||
[[Category: Einsle O]] | |||
[[Category: Gerbig-Smentek E]] | |||
[[Category: Lue W]] | |||
[[Category: Wacker T]] | |||
Latest revision as of 17:11, 1 November 2023
Formate Channel FocA from Salmonella typhimurium
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