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New page: left|200px<br /><applet load="2pbr" size="350" color="white" frame="true" align="right" spinBox="true" caption="2pbr, resolution 1.96Å" /> '''Crystal structure of...
 
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[[Image:2pbr.jpg|left|200px]]<br /><applet load="2pbr" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2pbr, resolution 1.96&Aring;" />
'''Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5'''<br />


==About this Structure==
==Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5==
2PBR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PBR OCA].  
<StructureSection load='2pbr' size='340' side='right'caption='[[2pbr]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
[[Category: Aquifex aeolicus]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[2pbr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus_VF5 Aquifex aeolicus VF5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PBR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PBR FirstGlance]. <br>
[[Category: dTMP kinase]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
[[Category: Ebihara, A.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Jeyakanthan, J.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pbr OCA], [https://pdbe.org/2pbr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pbr RCSB], [https://www.ebi.ac.uk/pdbsum/2pbr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pbr ProSAT], [https://www.topsan.org/Proteins/RSGI/2pbr TOPSAN]</span></td></tr>
[[Category: Kanaujia, S.P.]]
</table>
[[Category: Kuramitsu, S.]]
== Function ==
[[Category: Nakagawa, N.]]
[https://www.uniprot.org/uniprot/KTHY_AQUAE KTHY_AQUAE] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
== Evolutionary Conservation ==
[[Category: Ranjani, C.Vasuki.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Sekar, K.]]
Check<jmol>
[[Category: Shinkai, A.]]
  <jmolCheckbox>
[[Category: Shiro, Y.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pb/2pbr_consurf.spt"</scriptWhenChecked>
[[Category: Yokoyama, S.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: SO4]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: atp-binding]]
  </jmolCheckbox>
[[Category: kinase]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pbr ConSurf].
[[Category: national project on protein structural and functional analyses]]
<div style="clear:both"></div>
[[Category: nppsfa]]
[[Category: nucleotide biosynthesis]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomics]]
[[Category: tmp-binding]]
[[Category: transferase]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 13:19:21 2008''
==See Also==
*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]
__TOC__
</StructureSection>
[[Category: Aquifex aeolicus VF5]]
[[Category: Large Structures]]
[[Category: Ebihara A]]
[[Category: Jeyakanthan J]]
[[Category: Kanaujia SP]]
[[Category: Kuramitsu S]]
[[Category: Nakagawa N]]
[[Category: Sekar K]]
[[Category: Shinkai A]]
[[Category: Shiro Y]]
[[Category: Vasuki Ranjani C]]
[[Category: Yokoyama S]]
Retrieved from "https://proteopedia.org/2pbr"