3o8a: Difference between revisions

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[[Image:3o8a.png|left|200px]]


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==Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with novel Inhibitor Genz667348==
The line below this paragraph, containing "STRUCTURE_3o8a", creates the "Structure Box" on the page.
<StructureSection load='3o8a' size='340' side='right'caption='[[3o8a]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3o8a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O8A FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=O8A:N-CYCLOPROPYL-5-[2-METHYL-5-(TRIFLUOROMETHOXY)-1H-BENZIMIDAZOL-1-YL]THIOPHENE-2-CARBOXAMIDE'>O8A</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene></td></tr>
{{STRUCTURE_3o8a| PDB=3o8a |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o8a OCA], [https://pdbe.org/3o8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o8a RCSB], [https://www.ebi.ac.uk/pdbsum/3o8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o8a ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PYRD_PLAF7 PYRD_PLAF7] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o8/3o8a_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3o8a ConSurf].
<div style="clear:both"></div>


===Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with novel Inhibitor Genz667348===
==See Also==
 
*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]
 
__TOC__
<!--
</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_20702404}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 20702404 is the PubMed ID number.
[[Category: Plasmodium falciparum 3D7]]
-->
[[Category: Booker ML]]
{{ABSTRACT_PUBMED_20702404}}
[[Category: Deng X]]
 
[[Category: Phillips MA]]
==About this Structure==
[[3o8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O8A OCA].
 
==Reference==
<ref group="xtra">PMID:20702404</ref><references group="xtra"/>
[[Category: Dihydroorotate dehydrogenase]]
[[Category: Plasmodium falciparum]]
[[Category: Booker, M L.]]
[[Category: Deng, X.]]
[[Category: Phillips, M A.]]

Latest revision as of 10:33, 21 February 2024

Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with novel Inhibitor Genz667348

3o8a, resolution 2.30Å

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