3pdn: Difference between revisions

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[[Image:3pdn.png|left|200px]]


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==Crystal structure of SmyD3 in complex with methyltransferase inhibitor sinefungin==
The line below this paragraph, containing "STRUCTURE_3pdn", creates the "Structure Box" on the page.
<StructureSection load='3pdn' size='340' side='right'caption='[[3pdn]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3pdn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PDN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PDN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3pdn|  PDB=3pdn  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pdn OCA], [https://pdbe.org/3pdn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pdn RCSB], [https://www.ebi.ac.uk/pdbsum/3pdn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pdn ProSAT]</span></td></tr>
 
</table>
===Crystal structure of SmyD3 in complex with methyltransferase inhibitor sinefungin===
== Function ==
 
[https://www.uniprot.org/uniprot/SMYD3_HUMAN SMYD3_HUMAN] Histone methyltransferase. Specifically methylates 'Lys-4' and 'Lys-5' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences.<ref>PMID:15235609</ref> <ref>PMID:22419068</ref>
 
== References ==
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<references/>
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{{ABSTRACT_PUBMED_21167177}}
 
==About this Structure==
[[3pdn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PDN OCA].  
 
==Reference==
<ref group="xtra">PMID:21167177</ref><references group="xtra"/>
[[Category: Histone-lysine N-methyltransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Brunzelle, J.]]
[[Category: Large Structures]]
[[Category: Sirinupong, N.]]
[[Category: Brunzelle J]]
[[Category: Yang, Z.]]
[[Category: Sirinupong N]]
[[Category: Yang Z]]
Retrieved from "https://proteopedia.org/3pdn"