2l8e: Difference between revisions
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New page: '''Unreleased structure''' The entry 2l8e is ON HOLD Authors: Ilangovan, U., Kim, C. Description: 1H, 15N & 13C Chemical Shift assignments for FCS domain of HPH |
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==Solution NMR structure of FCS domain of Human Polyhomeotic Homolog 1 (HPH1)== | |||
<StructureSection load='2l8e' size='340' side='right'caption='[[2l8e]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2l8e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L8E FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l8e OCA], [https://pdbe.org/2l8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l8e RCSB], [https://www.ebi.ac.uk/pdbsum/2l8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l8e ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/PHC1_HUMAN PHC1_HUMAN] Autosomal recessive primary microcephaly. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PHC1_HUMAN PHC1_HUMAN] Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression.<ref>PMID:23418308</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Ilangovan U]] | |||
[[Category: Kim C]] | |||
