A Disintegrin And Metalloproteinase: Difference between revisions

From Proteopedia
Jump to navigationJump to search
New page: left|200px|thumb|Crystal structure of A Disintegrin And Metalloproteinase [[2ao7]] {{STRUCTURE_2ao7| PDB=2ao7 | SIZE=300| SCENE= |right|CAPTION=A Disintegrin And Metal...
 
Michal Harel (talk | contribs)
32,849 edits
No edit summary
 
(55 intermediate revisions by 3 users not shown)
Line 1: Line 1:
[[Image:2ao7.png|left|200px|thumb|Crystal structure of A Disintegrin And Metalloproteinase [[2ao7]]]]
<StructureSection load='' size='350' side='right' scene='43/436101/Cv/2' caption='A Disintegrin And Metalloproteinase complex with sulfate [[2ao7]]'>
{{STRUCTURE_2ao7|  PDB=2ao7  | SIZE=300| SCENE= |right|CAPTION=A Disintegrin And Metalloproteinase [[2ao7]] }}


[[A Disintegrin And Metalloproteinase]] (ADAM)  are peptidases which cleave off extracellular portions of transmembrane proteins.  ADAM inhibitors are used in anti-cancer therapy.  ADAM family members are numbered.  ADAM10 cleaves ephrin.  ADAM17 processes the tumor necrosis factor-α.  ADAM33 is implicated in asthma. The images at the left and at the right correspond to one representative ADAM, ''i.e.'' the crystal structure of bovine A Disintegrin And Metalloproteinase 10 ([[2ao7]]).
== Function ==


{{TOC limit|limit=2}}
[[A Disintegrin And Metalloproteinase]] (ADAM)  are peptidases which cleave off extracellular portions of transmembrane proteins.  ADAM family members are numbered.<br />
<br />
* '''ADAM10''' cleaves ephrin.<br />
<br />
* '''ADAM13''' details are in [[Molecular Playground/ADAM13]].<br />
<br />
* '''ADAM17''' (TACE or TNF-α converting enzyme) processes the tumor necrosis factor-α.<br />
<br />
* '''ADAM33''' is implicated in asthma.<br />
<br />
* '''ADAMTS''' is ADAM with thrombospondin motifs<ref>PMID:15554875</ref>. <br />
<br />
* '''ADAMTS1''' has anti-angionenic activity<ref>PMID:10811842</ref>. <br />
* '''ADAMTS4''' and '''ADAMTS5''' are involved in the degradation of aggrecan.<br />
*  '''ADAMTS13''' cleaves [[Von Willebrand Factor]] involved in blood clotting<ref>PMID:18762209</ref>.
== Disease ==
 
ADAM inhibitors are used in anti-cancer therapy.  '''ADAM10''' is a therapeutic target for cancer and inflammation <ref>PMID:19601831</ref>.  '''ADAM17''' is a therapeutic target for multiple diseases <ref>PMID:19601834</ref>. '''ADAM33''' is implicated in asthma.    '''ADAM33''' is a therapeutic target for asthma <ref>PMID:38396994</ref>.  '''ADAMTS4''' is involved  in various CNS pathologies<ref>PMID:28084617</ref>.


== 3D Structures of A Disintegrin And Metalloproteinase ==
== 3D Structures of A Disintegrin And Metalloproteinase ==
[[A Disintegrin And Metalloproteinase 3D structures]]


</StructureSection>


 
== References ==
===ADAM10===
<references/>
 
[[2ao7]] – ADAM10 - bovine<br />
 
===ADAM17===
 
[[1zxc]], [[2a8h]], [[2ddf]] – hADAM17 catalytic domain + inhibitor – human<br />
[[2fv5]], [[2fv9]], [[2i47]], [[3b92]], [[3cki]], [[3e8r]], [[3edz]], [[3ewj]], [[3g42]], [[3l0t]], [[3l0v]], [[3le9]], [[3lea]], [[3lgp]] - hADAM17 catalytic domain (mutant)+ inhibitor<br />
 
===ADAM33===
 
[[1r54]], [[1r55]] – hADAM33 catalytic domain<br />
 
[[Category:Topic Page]]
[[Category:Topic Page]]
Retrieved from "https://proteopedia.org/A_Disintegrin_And_Metalloproteinase"