2ktd: Difference between revisions

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[[Image:2ktd.jpg|left|200px]]


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==Solution structure of mouse lipocalin-type prostaglandin D synthase / substrate analog (U-46619) complex==
The line below this paragraph, containing "STRUCTURE_2ktd", creates the "Structure Box" on the page.
<StructureSection load='2ktd' size='340' side='right'caption='[[2ktd]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2ktd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KTD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KTD FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PUC:(5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-HYDROXYOCT-1-EN-1-YL]-2-OXABICYCLO[2.2.1]HEPT-5-YL}HEPT-5-ENOIC+ACID'>PUC</scene></td></tr>
{{STRUCTURE_2ktd|  PDB=2ktd  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ktd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ktd OCA], [https://pdbe.org/2ktd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ktd RCSB], [https://www.ebi.ac.uk/pdbsum/2ktd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ktd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PTGDS_MOUSE PTGDS_MOUSE] Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.<ref>PMID:8922532</ref> <ref>PMID:9892701</ref> <ref>PMID:10781097</ref> <ref>PMID:11751991</ref> <ref>PMID:12077186</ref> <ref>PMID:17715133</ref> <ref>PMID:19546224</ref> <ref>PMID:19833210</ref>


===Solution structure of mouse lipocalin-type prostaglandin D synthase / substrate analog (U-46619) complex===
==See Also==
 
*[[Prostaglandin D synthase|Prostaglandin D synthase]]
 
== References ==
==About this Structure==
<references/>
[[2ktd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KTD OCA].
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Prostaglandin-D synthase]]
[[Category: Kato N]]
[[Category: Kato, N.]]
[[Category: Maruo H]]
[[Category: Maruo, H.]]
[[Category: Ohkubo T]]
[[Category: Ohkubo, T.]]
[[Category: Shimamoto S]]
[[Category: Shimamoto, S.]]
[[Category: Yoshida T]]
[[Category: Yoshida, T.]]
Retrieved from "https://proteopedia.org/2ktd"