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[[Image:2uzg.jpg|left|200px]]<br /><applet load="2uzg" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2uzg" />
'''ZF-UBP DOMAIN OF VDU1'''<br />


==Overview==
==Zf-UBP domain of VDU1==
USP33/VDU1 is a deubiquitinating enzyme that binds to the von, Hippel-Lindau tumor suppressor protein. It also regulates thyroid hormone, activation by deubiquitinating type 2 iodothyronine deiodinase. USP33/VDU1, contains a ZF UBP domain, a protein module found in many proteins in the, ubiquitin-proteasome system. Several ZF UBP domains have been shown to, bind ubiquitin, and a structure of a complex of the ZF UBP domain of, isoT/USP5 and ubiquitin is available. In the present work, the solution, structure of the ZF UBP domain of USP33/VDU1 has been determined by NMR, spectroscopy. The structure differs from that of the USP5 domain, which, contains only one of the three Zn ions present in the USP33/VDU1, structure. The USP33/VDU1 ZnF UBP domain does not bind to ubiquitin.
<StructureSection load='2uzg' size='340' side='right'caption='[[2uzg]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2uzg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UZG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uzg OCA], [https://pdbe.org/2uzg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uzg RCSB], [https://www.ebi.ac.uk/pdbsum/2uzg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uzg ProSAT]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uz/2uzg_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uzg ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
USP33/VDU1 is a deubiquitinating enzyme that binds to the von Hippel-Lindau tumor suppressor protein. It also regulates thyroid hormone activation by deubiquitinating type 2 iodothyronine deiodinase. USP33/VDU1 contains a ZF UBP domain, a protein module found in many proteins in the ubiquitin-proteasome system. Several ZF UBP domains have been shown to bind ubiquitin, and a structure of a complex of the ZF UBP domain of isoT/USP5 and ubiquitin is available. In the present work, the solution structure of the ZF UBP domain of USP33/VDU1 has been determined by NMR spectroscopy. The structure differs from that of the USP5 domain, which contains only one of the three Zn ions present in the USP33/VDU1 structure. The USP33/VDU1 ZnF UBP domain does not bind to ubiquitin.


==About this Structure==
The solution structure of the ZnF UBP domain of USP33/VDU1.,Allen MD, Bycroft M Protein Sci. 2007 Sep;16(9):2072-5. PMID:17766394<ref>PMID:17766394</ref>
2UZG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZG OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
The solution structure of the ZnF UBP domain of USP33/VDU1., Allen MD, Bycroft M, Protein Sci. 2007 Sep;16(9):2072-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17766394 17766394]
</div>
[[Category: Homo sapiens]]
<div class="pdbe-citations 2uzg" style="background-color:#fffaf0;"></div>
[[Category: Single protein]]
[[Category: Allen, M.D.]]
[[Category: Bycroft, M.]]
[[Category: ZN]]
[[Category: alternative splicing]]
[[Category: de-ubiquitination]]
[[Category: hydrolase]]
[[Category: metal-binding]]
[[Category: protease]]
[[Category: thiol protease]]
[[Category: ubl conjugation]]
[[Category: ubl conjugation pathway]]
[[Category: vdu1]]
[[Category: zf-ubp]]
[[Category: zinc]]
[[Category: zinc-finger]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 13:37:51 2008''
==See Also==
*[[Thioesterase 3D structures|Thioesterase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Allen, M D]]
[[Category: Bycroft, M]]
[[Category: Alternative splicing]]
[[Category: De-ubiquitination]]
[[Category: Hydrolase]]
[[Category: Metal-binding]]
[[Category: Protease]]
[[Category: Thiol protease]]
[[Category: Ubl conjugation]]
[[Category: Ubl conjugation pathway]]
[[Category: Vdu1]]
[[Category: Zf-ubp]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
Retrieved from "https://proteopedia.org/2uzg"