3odm: Difference between revisions

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==Archaeal-type phosphoenolpyruvate carboxylase==
The line below this paragraph, containing "STRUCTURE_3odm", creates the "Structure Box" on the page.
<StructureSection load='3odm' size='340' side='right'caption='[[3odm]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3odm]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ODM FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AUC:GOLD+(I)+CYANIDE+ION'>AUC</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
{{STRUCTURE_3odm|  PDB=3odm  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3odm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3odm OCA], [https://pdbe.org/3odm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3odm RCSB], [https://www.ebi.ac.uk/pdbsum/3odm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3odm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAPPA_CLOPE CAPPA_CLOPE] Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.<ref>PMID:19923749</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of an archaeal-type phosphoenolpyruvate carboxylase from Clostridium perfringens has been determined based on X-ray data extending to 3 A. The asymmetric unit of the structure includes two tetramers (each a dimer-of-dimers) of the enzyme. The precipitant, malonate, employed for the crystallization is itself a weak inhibitor of phosphoenolpyruvate carboxylase and a malonate molecule is seen in the active-site in the crystal structure. The allosteric binding sites for aspartate (an inhibitor) and glucose-6-phosphate (an activator) observed in the Escherichia coli and Zea mays phosphoenolpyruvate carboxylase structures, respectively, are not conserved in the C. perfringens structure. Aspartate inhibits the C. perfringens enzyme competitively with respect to the substrate, Mg(++.) phosphoenolpyruvate. A mechanism for inhibition is proposed based on the structure and sequence comparisons with other archaeal-type phosphoenolpyruvate carboxylases with differing sensitivity to inhibition by aspartate. Proteins 2011; (c) 2011 Wiley-Liss, Inc.


===Archaeal-type phosphoenolpyruvate carboxylase===
Structure of an archaeal-type phosphoenolpyruvate carboxylase sensitive to inhibition by aspartate.,Dharmarajan L, Kraszewski JL, Mukhopadhyay B, Dunten PW Proteins. 2011 Feb 3. doi: 10.1002/prot.23006. PMID:21491491<ref>PMID:21491491</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3odm" style="background-color:#fffaf0;"></div>


==About this Structure==
==See Also==
[[3odm]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODM OCA].
*[[Phosphoenolpyruvate carboxylase|Phosphoenolpyruvate carboxylase]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:19923749</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Clostridium perfringens]]
[[Category: Clostridium perfringens]]
[[Category: Phosphoenolpyruvate carboxylase]]
[[Category: Large Structures]]
[[Category: Dunten, P W.]]
[[Category: Dunten PW]]

Latest revision as of 09:56, 13 August 2026

Archaeal-type phosphoenolpyruvate carboxylase

3odm, resolution 2.95Å

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