3pz4: Difference between revisions

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~~'''Unreleased structure'''~~

The ~~entry 3pz4~~ is ~~ON HOLD until Paper Publication~~

==Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BMS3 and lipid substrate FPP==

== Structural highlights ==

<table><tr><td colspan='2'>[[3pz4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ4 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=3PZ4 FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PZ:(3R)-3-BENZYL-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPINE-7-CARBONITRILE'>3PZ</scene>, <scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=3pz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz4 OCA], [https://pdbe.org/3pz4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pz4 RCSB], [https://www.ebi.ac.uk/pdbsum/3pz4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pz4 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity).

~~Authors~~: ~~Guo, Z., Bon, R.S., Stigter, E.A., Waldmann, H.,~~ Alexandrov, K., Blankenfeldt, W., Goody~~, R.S.~~

==See Also==

*[[Farnesyltransferase 3D structures|Farnesyltransferase 3D structures]]

~~Description~~: ~~Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BMS3 and lipid substrate FPP~~

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Rattus norvegicus]]

[[Category: Alexandrov K]]

[[Category: Blankenfeldt W]]

[[Category: Bon RS]]

[[Category: Goody RS]]

[[Category: Guo Z]]

[[Category: Stigter EA]]

[[Category: Waldmann H]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 3pz4 is ON HOLD  until Paper Publication
+==Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BMS3 and lipid substrate FPP==
+<StructureSection load='3pz4' size='340' side='right'caption='[[3pz4]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3pz4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PZ4 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PZ:(3R)-3-BENZYL-4-[(4-METHOXYPHENYL)SULFONYL]-1-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPINE-7-CARBONITRILE'>3PZ</scene>, <scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz4 OCA], [https://pdbe.org/3pz4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pz4 RCSB], [https://www.ebi.ac.uk/pdbsum/3pz4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pz4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity).
-Authors: Guo, Z., Bon, R.S., Stigter, E.A., Waldmann, H., Alexandrov, K., Blankenfeldt, W., Goody, R.S.
+==See Also==
+*[[Farnesyltransferase 3D structures|Farnesyltransferase 3D structures]]
-Description: Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BMS3 and lipid substrate FPP
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Rattus norvegicus]]
+[[Category: Alexandrov K]]
+[[Category: Blankenfeldt W]]
+[[Category: Bon RS]]
+[[Category: Goody RS]]
+[[Category: Guo Z]]
+[[Category: Stigter EA]]
+[[Category: Waldmann H]]